Pathway to Prevention of Type 1 Diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance understanding of the natural history and risk factors associated with type 1 diabetes (T1D) by screening individuals for diabetes-related autoantibodies. Participants undergo a simple blood test to identify the presence of these autoantibodies, which can indicate an increased risk of developing T1D. Those who test positive will receive further testing to assess their risk over the next five years, with follow-up visits scheduled based on their autoantibody status. The study is part of an international effort to develop prevention strategies for T1D.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals 2 to 45 years old who have an immediate family member with type 1 diabetes (such as a child, parent, or sibling)
* Individuals 2-20 years old who have an extended family member with type 1 diabetes (such as a cousin, niece, nephew, aunt, uncle, grandparent, or half-sibling)
* Those aged 2 years to 45 years who are not family members and are known to have 1 or more islet antibodies

Exclusion Criteria:

To be eligible a person must not:

* Have diabetes already
* Have previous or current use of medications for the control of hyperglycemia/diabetes.
* Currently be using immunosuppressive or immunomodulatory agents (topical and inhaled agents are acceptable)
* Have known severe active diseases, and/or diseases which are likely to limit life expectancy or lead to the use of chronic immunosuppressive or immunomodulatory therapies during the course of the study

Where it's running

• Childrens Hospital of Orange County
  Orange, California, United States Recruiting
• University of California San Francisco
  San Francisco, California, United States Recruiting
• Stanford University Medical Center
  Stanford, California, United States Recruiting
• Barbara Davis Center for Childhood Diabetes
  Denver, Colorado, United States Recruiting
• Yale University School of Medicine
  New Haven, Connecticut, United States Recruiting
• University of Florida
  Gainesville, Florida, United States Recruiting

Study contacts

• Study coordinator: TrialNet Central Information Center general info
• Phone: 1-800-425-8361

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Home-based use of an advanced hybrid closed-loop insulin pump with telemonitoring for adults with type 1 diabetes

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• Diabetes multimorbidity and a voice diary app to help self-manage

  This study tests whether the Fabla-diabetesMM audio diary app is feasible and helpful for older adults with type 1 or type 2 diabetes who also have additional chronic conditions.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.