Understanding the genetics of autoimmune responses in type 1 diabetes
Official title: Genetics Of Autoimmunity In Type I Diabetes
Run by Medical College of Wisconsin · NCT03648918 · Data updated 2026-11-12
This study is trying to understand how genes and the environment affect the development of type 1 diabetes by looking at families with a history of the disease and healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years and up |
| Sex | All |
| Enrollment | 4000 (estimated) |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Status | Recruiting |
| Started | August 2001 |
| Main results expected | January 2050 |
| Study ends | January 2050 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT03648918 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include families with at least one first-degree relative diagnosed with type 1 diabetes and healthy individuals with no autoimmune disease history.
✕Probably not a fit
Patients with no family history of type 1 diabetes or those with other types of diabetes will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the genetic and environmental factors that contribute to the development of type 1 diabetes (T1D). Participants, including families with a history of T1D and healthy controls, will undergo blood draws, medical history questionnaires, and physical measurements. The study will analyze immune system responses and genetic markers related to T1D susceptibility. Some participants may return for annual follow-up visits over a period of 10 years to track disease progression and factors influencing it.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and prevention strategies for type 1 diabetes.
How similar studies have gone: Other studies have shown success in understanding autoimmune diseases through genetic and environmental analysis, making this approach promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria (Families): * Families where at least one first-degree family member has type 1 diabetes * The diabetic proband in the family was diagnosed before the age of 39 * Family members must be at least 2 years old to participate Exclusion Criteria (Families): * Families with no history of type 1 diabetes * Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.) Inclusion Criteria (Controls): * No family history of type 1 diabetes or other autoimmune conditions * Age 2 or older Exclusion Criteria (Controls): * Personal or family history of autoimmune disease
Where it's running
-
Medical College of Wisconsin
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Martin Hessner, PhD — Medical College of Wisconsin
- Study coordinator: Martin Hessner, PhD
- Email: t1dinfo@mcw.edu
- Phone: 414-955-4903
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.