Understanding the genetics of autoimmune responses in type 1 diabetes
Genetics Of Autoimmunity In Type I Diabetes
This study is trying to understand how genes and the environment affect the development of type 1 diabetes by looking at families with a history of the disease and healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 4000 (estimated) |
| Ages | 2 Years and up |
| Sex | All |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT03648918 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic and environmental factors that contribute to the development of type 1 diabetes (T1D). Participants, including families with a history of T1D and healthy controls, will undergo blood draws, medical history questionnaires, and physical measurements. The study will analyze immune system responses and genetic markers related to T1D susceptibility. Some participants may return for annual follow-up visits over a period of 10 years to track disease progression and factors influencing it.
Who should consider this trial
Good fit: Ideal candidates include families with at least one first-degree relative diagnosed with type 1 diabetes and healthy individuals with no autoimmune disease history.
Not a fit: Patients with no family history of type 1 diabetes or those with other types of diabetes will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and prevention strategies for type 1 diabetes.
How similar studies have performed: Other studies have shown success in understanding autoimmune diseases through genetic and environmental analysis, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria (Families): * Families where at least one first-degree family member has type 1 diabetes * The diabetic proband in the family was diagnosed before the age of 39 * Family members must be at least 2 years old to participate Exclusion Criteria (Families): * Families with no history of type 1 diabetes * Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.) Inclusion Criteria (Controls): * No family history of type 1 diabetes or other autoimmune conditions * Age 2 or older Exclusion Criteria (Controls): * Personal or family history of autoimmune disease
Where this trial is running
Milwaukee, Wisconsin
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Martin Hessner, PhD — Medical College of Wisconsin
- Study coordinator: Martin Hessner, PhD
- Email: t1dinfo@mcw.edu
- Phone: 414-955-4903
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.