Condition

Bipolar I Disorder clinical trials and research

• 16Clinical trials
• 1NIH research projects
• 12Countries

Newest Bipolar I Disorder clinical trials

All recruiting trials (16)

• SCC Deep Brain Stimulation for Bipolar Depression in Bipolar I Patients

  A small study tests whether deep brain stimulation of the subcallosal cingulate can help people with bipolar I depression who have not improved with other treatments, while monitoring brain signals to watch for manic switches.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07745374

• Comparing an oral crystallized lithium capsule (AL001) with immediate‑release lithium carbonate in adults with Bipolar I Disorder

  This project will test whether a new crystallized lithium capsule called AL001 is as safe and reaches the brain differently than standard immediate‑release lithium carbonate in adults with Bipolar I Disorder.

  Recruiting Phase 1/2 Alzamend Neuro, Inc. · Boston, Massachusetts · NCT07540338

• LB-102 for adults with Bipolar I major depressive episodes

  This trial will test whether taking LB-102 once daily helps adults with Bipolar I disorder who are currently in a major depressive episode, compared with a placebo, over 6 weeks.

  Recruiting at 26 sites Phase 2 LB Pharmaceuticals Inc. · Bentonville, Arkansas and 25 other locations · NCT07494305

• NBI-1117568 for adults with Bipolar I disorder experiencing current mania

  This trial will test whether NBI-1117568 reduces manic symptoms in adults with Bipolar I disorder who are currently having a manic episode.

  Recruiting at 11 sites Phase 2 Neurocrine Biosciences · Little Rock, Arkansas and 10 other locations · NCT07288320

• Personalized weight-loss medication plan for adults with bipolar disorder

  This pilot tests whether matching FDA-approved weight-loss medicines to specific obesity types helps adults aged 18–65 with bipolar disorder lose weight.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07213466

• Monthly subcutaneous long-acting cariprazine injection for adults with schizophrenia, bipolar I disorder, or major depressive disorder.

  This will test a once-a-month subcutaneous long-acting form of cariprazine for adults with schizophrenia, bipolar I disorder, or major depressive disorder who are eligible for the oral medication.

  Recruiting at 6 sites Phase 1/2 Mapi Pharma Ltd. · Ahmedabad and 5 other locations · NCT07185815

• Assessing mental health disorders in Hong Kong using a new recall method

  This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.

  Recruiting The University of Hong Kong · Hong Kong · NCT06804525

• Oral icalcaprant for adults with bipolar I or II: safety and symptom change

  This trial will test whether taking oral icalcaprant once daily for six weeks is safe and helps reduce depressive symptoms in adults with bipolar I or II disorder.

  Recruiting at 33 sites Phase 2 AbbVie · Huntsville, Alabama and 32 other locations · NCT06696755

• Synchronized eating for bipolar depression

  This trial will test whether limiting eating to a 10-hour daily window plus usual care helps adults aged 18–55 with bipolar depression compared with nutritional counselling plus usual care.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT06560957

• Ketogenic diet and nutritional interventions for first episode bipolar disorder

  This study is testing if a ketogenic diet, along with regular treatment, can help people who are having their first episode of bipolar disorder or schizoaffective disorder feel better and improve their brain health.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT06221852

• Using NMDA receptor modulation to treat cognitive impairment in bipolar I disorder

  This study is testing a new treatment to see if it can help improve thinking skills and reduce stress in adults with bipolar I disorder who are having depressive episodes.

  Recruiting Phase 2 China Medical University Hospital · Taichung · NCT05977023

• Using Magnesium and Vitamin B6 to Treat First Episode Bipolar Disorder

  This study is testing if adding magnesium and vitamin B6 to standard treatment can help people who are having their first episode of bipolar disorder feel better and recover more effectively.

  Recruiting Phase 2 Mclean Hospital · Belmont, Massachusetts · NCT05837104

• Evaluating the safety of iloperidone in adolescents with schizophrenia or bipolar disorder

  This study is testing how safe the medication iloperidone is for teenagers aged 12 to 17 who have schizophrenia or bipolar disorder.

  Recruiting at 11 sites Phase 4 Vanda Pharmaceuticals · Dothan, Alabama and 10 other locations · NCT05648591

• Naturalistic treatment and follow-up for youth with bipolar spectrum disorders

  This study looks at young people aged 9 to 19 with bipolar spectrum disorders to see how well they do over a year while receiving standard treatments and tracking their progress.

  Recruiting University of California, Los Angeles · Los Angeles, California and 3 other locations · NCT05427123

• Evaluating weight gain in children with schizophrenia or bipolar disorder

  This study is testing if a new treatment can help children with schizophrenia or bipolar disorder manage weight gain caused by their current medication.

  Recruiting at 35 sites Phase 3 Alkermes, Inc. · Dothan, Alabama and 46 other locations · NCT05303064

• Assessing Cariprazine for Treating Depression in Teens with Bipolar I Disorder

  This study is testing if a medication called cariprazine can help teenagers with bipolar I disorder feel better during depressive episodes.

  Recruiting at 32 sites Phase 3 AbbVie · Bentonville, Arkansas and 80 other locations · NCT04777357

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding the development of bipolar I disorder in young people

  This study is looking at how bipolar I disorder starts in young people, especially those with a family history of the condition, by exploring how genes and early life experiences might lead to symptoms like mania, with the goal of finding early warning signs and better ways to help them.

  NIH research University of Texas at Austin · Austin, United States · NIH-11111169

Related topics

Quick answers

How many Bipolar I Disorder clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (12 trials), Taiwan (1 trial), Argentina (1 trial), Brazil (1 trial), Colombia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 2, Phase 4: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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