Using Acceptance and Commitment Therapy to help Black adolescents cope with race-related stress
Official title: Using Acceptance and Commitment Therapy (ACT) to Promote Mental Health and Transition Readiness in Youth With Sickle Cell Disease: A Community-Based Participatory Action Research (CBPAR) Approach
Run by Children's Hospital Los Angeles · NCT05685368 · Data updated 2026-11-12
This study is testing whether Acceptance and Commitment Therapy can help Black teenagers cope better with stress, anxiety, and depression related to race-related challenges.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 14 Years to 21 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Children's Hospital Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | June 30, 2029 |
| Study ends | June 30, 2029 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT05685368 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Black or African American adolescents who are English-speaking and can engage meaningfully in the therapy process.
✕Probably not a fit
Patients who are currently experiencing psychosis, severe health concerns, or are at significant risk for suicide may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the feasibility and acceptability of Acceptance and Commitment Therapy (ACT) for Black adolescents facing race-related stress. It involves a small, non-randomized sample of 30 participants who will engage in a 10-session ACT group as part of their regular clinical care. The study aims to support these individuals in managing stress, anxiety, and depression linked to their experiences of racial stigma. Three consecutive groups will be conducted, each consisting of 8-10 participants over the course of a year.
Why it matters
Potential benefit: If successful, this approach could significantly improve the mental health and quality of life for Black adolescents experiencing race-related stress.
How similar studies have gone: Previous studies have shown the efficacy of Acceptance and Commitment Therapy in addressing stigma, suggesting potential success for this approach in a similar context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Youth Participant Inclusion and Exclusion Criteria The inclusion criteria for study participation are Be an adolescent and/or young adult (age 14-21) who has Sickle Cell Disease Willing to enroll in the ACT group jointly provided by the Division of Adolescent and Young Adult Medicine/Department of Hematology and Oncology Participants can be active, waitlisted, or new patients at CHLA Participants must be able to understand and speak English, as the therapy will only be delivered in English Participants must have an English-speaking parent/guardian Able to provide consent/assent An adolescent or young adult that is pregnant is eligible to participate if consent can be obtained Participants must be developmentally typical Have a stable internet connection (via computer, tablet, or phone) with access to a webcam and a private space to engage in a group therapy sessions; Must consent to audio and video recording of initial interview. Must agree to attend 6 weekly ACT group session Youth participants will be asked to become a member of the CAB. To become a CAB member, the youth participant must consent/assent to participation in the ACT intervention. If a CAB member, they must be willing to engage in CAB interviews and meetings. The exclusion criteria are: Prisoners or youth in detention centers Unable to understand or speak English Does not have SCD Clients who are at significant risk for suicide and self-injury will be excluded due to the intense levels of support required to support these individuals which would interfere with study procedures. Adolescents with families that require frequent intervention from the Department of Children and Family Services, are currently experiencing psychosis, or have severe health concerns that will impact study participation or attendance will be excluded.
Where it's running
-
Children's Hospital Los Angeles
Los Angeles, California, United States Recruiting
Study contacts
- Principal investigator: Xzania Lee, PhD — Children's Hospital Los Angeles
- Study coordinator: Xzania Lee, PhD
- Email: xlee@chla.usc.edu
- Phone: 323.361.4768
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.