Clinical trial Recruiting at 1 site Phase1; Phase2 Interventional Ages 14 to 21

Using Acceptance and Commitment Therapy to help Black adolescents cope with race-related stress

Official title: Using Acceptance and Commitment Therapy (ACT) to Promote Mental Health and Transition Readiness in Youth With Sickle Cell Disease: A Community-Based Participatory Action Research (CBPAR) Approach

Run by Children's Hospital Los Angeles · NCT05685368 · Data updated 2026-11-12

This study is testing whether Acceptance and Commitment Therapy can help Black teenagers cope better with stress, anxiety, and depression related to race-related challenges.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages14 Years to 21 Years
SexAll
Enrollment66 (estimated)
SponsorChildren's Hospital Los Angeles
Academic / other
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedApril 1, 2025
Main results expectedJune 30, 2029
Study endsJune 30, 2029
Registry record updatedMay 6, 2026
Trial IDNCT05685368 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Black or African American adolescents who are English-speaking and can engage meaningfully in the therapy process.

Probably not a fit

Patients who are currently experiencing psychosis, severe health concerns, or are at significant risk for suicide may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility and acceptability of Acceptance and Commitment Therapy (ACT) for Black adolescents facing race-related stress. It involves a small, non-randomized sample of 30 participants who will engage in a 10-session ACT group as part of their regular clinical care. The study aims to support these individuals in managing stress, anxiety, and depression linked to their experiences of racial stigma. Three consecutive groups will be conducted, each consisting of 8-10 participants over the course of a year.

Why it matters

Potential benefit: If successful, this approach could significantly improve the mental health and quality of life for Black adolescents experiencing race-related stress.

How similar studies have gone: Previous studies have shown the efficacy of Acceptance and Commitment Therapy in addressing stigma, suggesting potential success for this approach in a similar context.

Who can join: the full rules

Show full inclusion / exclusion criteria
Youth Participant Inclusion and Exclusion Criteria The inclusion criteria for study participation are Be an adolescent and/or young adult (age 14-21) who has Sickle Cell Disease Willing to enroll in the ACT group jointly provided by the Division of Adolescent and Young Adult Medicine/Department of Hematology and Oncology Participants can be active, waitlisted, or new patients at CHLA Participants must be able to understand and speak English, as the therapy will only be delivered in English Participants must have an English-speaking parent/guardian Able to provide consent/assent An adolescent or young adult that is pregnant is eligible to participate if consent can be obtained Participants must be developmentally typical Have a stable internet connection (via computer, tablet, or phone) with access to a webcam and a private space to engage in a group therapy sessions; Must consent to audio and video recording of initial interview. Must agree to attend 6 weekly ACT group session Youth participants will be asked to become a member of the CAB. To become a CAB member, the youth participant must consent/assent to participation in the ACT intervention. If a CAB member, they must be willing to engage in CAB interviews and meetings.

The exclusion criteria are:

Prisoners or youth in detention centers Unable to understand or speak English Does not have SCD Clients who are at significant risk for suicide and self-injury will be excluded due to the intense levels of support required to support these individuals which would interfere with study procedures.

Adolescents with families that require frequent intervention from the Department of Children and Family Services, are currently experiencing psychosis, or have severe health concerns that will impact study participation or attendance will be excluded.

Where it's running

  • Children's Hospital Los Angeles
    Los Angeles, California, United States
    Recruiting

Study contacts

  • Principal investigator: Xzania Lee, PhD — Children's Hospital Los Angeles
  • Study coordinator: Xzania Lee, PhD
  • Email: xlee@chla.usc.edu
  • Phone: 323.361.4768

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.