Understanding the genetics of depression and anxiety
Official title: Expanding Genetic Understanding of Depression, Anxiety, and their Treatments
Funded at Yale University · NIH-11141904 · Data updated 2026-11-12
This study is looking at how our genes might influence major depression and anxiety disorders, using information from a large group of veterans, to help find better, more personalized treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $581,341 |
| NIH project number | 5R01MH133728-02 |
| Project ID | NIH-11141904 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of major depressive disorder or anxiety disorders, particularly those from diverse backgrounds.
✕Less likely to help
Patients who do not have a diagnosis of depression or anxiety may not receive direct benefits from this research.
What this research studies
This research investigates the genetic factors associated with major depressive disorder (MDD) and anxiety disorders (ANX) using data from the Veterans Affairs Million Veteran Program, which includes over 900,000 participants. By analyzing genetic information and extensive health data, the study aims to identify specific genetic risk factors and how they relate to these mental health conditions. The research will also explore the genetic predisposition to various anxiety-related disorders and subphenotypes, potentially leading to more personalized treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals suffering from depression and anxiety.
How similar studies have gone: Previous research using genetic analysis in large cohorts has shown promise in identifying risk factors for mental health disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Gelernter, Joel — Yale University
- Study coordinator: Gelernter, Joel
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.