Oliceridine vs Sufentanil for cough during anesthesia induction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, double-blind study comparing oliceridine to sufentanil for general anesthesia induction. The primary focus is on cough incidence and severity, with secondary assessments of hemodynamic responses and perioperative safety. Eligible adults are 18 to 99 years old with ASA I–III undergoing elective surgery and meeting BMI criteria, with exclusions for respiratory infection, airway hyperreactivity, significant organ disease, and recent opioid use. Randomization is concealed and both the surgeon and data recorder are blinded to treatment allocation. Participants in the oliceridine arm receive weight-based dosing, and the study aims to determine if the biased signaling profile of oliceridine reduces cough risk at induction while preserving analgesic efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 99 years.
* American Society of Anesthesiologists (ASA) physical status classification I, II, or III.
* Body mass index (BMI) between 18.5 and 28.0 kg/m².
* Scheduled for elective surgery under general anaesthesia.
* Able to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Preoperative upper respiratory tract infection symptoms (e.g., cough, expectoration, or fever) or a history of bronchial asthma or other conditions associated with increased airway reactivity.
* Severe cardiovascular disease (e.g., uncontrolled hypertension, recent myocardial infarction, or serious arrhythmia) or hepatic or renal dysfunction.
* Long-term opioid use, defined as continuous opioid use for more than 2 weeks within the 3 months prior to surgery.
* Known hypersensitivity to any study drug or anaesthetic agent used in this protocol.
* Anticipated difficult airway requiring awake intubation.
* Pregnancy or breastfeeding.

Where it's running

• Tianmen First People's Hospital
  Tianmen, Hubei, China Recruiting

Study contacts

• Study coordinator: Shiyou Wei, MD.
• Email: lovewishyou@tongji.edu.cn
• Phone: 15601680288

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.