Finding the best treatments for chronic cough
Official title: Identifying Predictors of Treatment Response to Pharmacologic and Nonpharmacologic Interventions in Cough Hypersensitivity Syndrome
Funded at Univ of North Carolina Chapel Hill · NIH-11162507 · Data updated 2026-11-12
This project aims to help doctors choose the most effective treatment for people with chronic cough by understanding what makes each person respond differently.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $142,804 |
| NIH project number | 5K23HL169934-02 |
| Project ID | NIH-11162507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21 and older who experience chronic coughing due to Cough Hypersensitivity Syndrome.
✕Less likely to help
Patients whose chronic cough is not due to Cough Hypersensitivity Syndrome or who do not meet the age criteria may not directly benefit from this specific research.
What this research studies
Many people suffer from chronic coughing, known as Cough Hypersensitivity Syndrome, which can lead to serious problems like broken ribs or fainting. Currently, doctors often use a trial-and-error approach to find the right treatment, choosing between medications or speech therapy. This can be frustrating and costly for patients. Our goal is to discover specific cough symptoms that can predict which treatment will work best for you, helping to personalize care. We believe that understanding these individual differences will lead to more accurate diagnoses and more effective, tailored treatments from the start.
Why it matters
Potential benefit: If successful, this work could help patients with chronic cough receive the most effective treatment sooner, avoiding unnecessary and ineffective therapies.
How similar studies have gone: While the general approach of tailoring treatments based on patient characteristics has shown promise in other areas, this specific method for predicting cough treatment response is novel.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Novaleski, Carolyn K. — Univ of North Carolina Chapel Hill
- Study coordinator: Novaleski, Carolyn K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.