Understanding and preventing lung problems after tuberculosis treatment
Identifying patients at risk of post-tuberculosis lung disease using novel cough and adherence predictors
This research aims to find new ways to identify people who are at risk of developing long-term lung issues after completing treatment for tuberculosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11194314 on NIH RePORTER |
What this research studies
Many people experience lasting lung problems, known as post-tuberculosis lung disease (PTLD), even after their tuberculosis treatment is finished. It can be hard to tell who will get better and who will get worse, especially in places where standard lung function tests are not readily available. This project will look at how lung function changes over time after TB treatment and how it affects daily life. We will also explore if using a mobile app to track cough sounds and frequency, along with how well patients stick to their treatment, can help us predict who is most at risk for PTLD.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals who have recently completed treatment for tuberculosis.
Not a fit: Patients who have not had tuberculosis or are currently undergoing active TB treatment would not be the focus of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to earlier identification of patients at risk for post-tuberculosis lung disease, allowing for timely interventions to improve their lung health and quality of life.
How similar studies have performed: While the burden of post-tuberculosis lung disease is increasingly recognized, this research explores novel, non-invasive methods like mobile app-based cough analysis for risk prediction, which is a relatively untested approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Huddart, Sophie — University of California, San Francisco
- Study coordinator: Huddart, Sophie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.