Understanding and preventing lung problems after tuberculosis treatment
Official title: Identifying patients at risk of post-tuberculosis lung disease using novel cough and adherence predictors
Funded at University of California, San Francisco · NIH-11194314 · Data updated 2026-11-12
This research aims to find new ways to identify people who are at risk of developing long-term lung issues after completing treatment for tuberculosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $174,420 |
| NIH project number | 5K01HL165039-03 |
| Project ID | NIH-11194314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals who have recently completed treatment for tuberculosis.
✕Less likely to help
Patients who have not had tuberculosis or are currently undergoing active TB treatment would not be the focus of this particular research.
What this research studies
Many people experience lasting lung problems, known as post-tuberculosis lung disease (PTLD), even after their tuberculosis treatment is finished. It can be hard to tell who will get better and who will get worse, especially in places where standard lung function tests are not readily available. This project will look at how lung function changes over time after TB treatment and how it affects daily life. We will also explore if using a mobile app to track cough sounds and frequency, along with how well patients stick to their treatment, can help us predict who is most at risk for PTLD.
Why it matters
Potential benefit: If successful, this work could lead to earlier identification of patients at risk for post-tuberculosis lung disease, allowing for timely interventions to improve their lung health and quality of life.
How similar studies have gone: While the burden of post-tuberculosis lung disease is increasingly recognized, this research explores novel, non-invasive methods like mobile app-based cough analysis for risk prediction, which is a relatively untested approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Huddart, Sophie — University of California, San Francisco
- Study coordinator: Huddart, Sophie
Related research
Other NIH-funded projects on the same topics.
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Understanding how cough spreads tuberculosis
This study is looking at how coughing helps spread the bacteria that cause tuberculosis (TB) so we can find better ways to prevent and treat the disease, especially for those at higher risk.
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Understanding how tuberculosis bacteria cause cough and spread
This study is looking at how the bacteria that cause tuberculosis can make people cough, which helps them spread the infection, and it aims to find out how this happens so we can better control the disease.
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Identifying patients at risk of lung disease after tuberculosis treatment
This study is looking for ways to help people who have finished their tuberculosis treatment by finding out who might develop lung problems later on, using new tools like a mobile app to track coughs instead of just relying on standard lung tests.
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Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.