Understanding how cough spreads tuberculosis
Official title: Project 3: Mechanisms of cough in M. tuberculosis transmission
Funded at Weill Medical Coll of Cornell Univ · NIH-11308397 · Data updated 2026-11-12
This study is looking at how coughing helps spread the bacteria that cause tuberculosis (TB) so we can find better ways to prevent and treat the disease, especially for those at higher risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 13, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $350,277 |
| NIH project number | 5P01AI159402-05 |
| Project ID | NIH-11308397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at high risk for tuberculosis transmission, such as those living in close quarters with infected individuals or those with compromised immune systems.
✕Less likely to help
Patients who are not at risk for tuberculosis or who have already been effectively treated for the disease may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which coughing contributes to the transmission of Mycobacterium tuberculosis, the bacteria responsible for tuberculosis (TB). By examining the biological processes involved in cough production and its role in spreading TB, the research aims to identify potential intervention points to reduce transmission. Patients may benefit from insights gained that could lead to improved prevention strategies and treatments for TB, particularly in high-risk populations.
Why it matters
Potential benefit: If successful, this research could lead to more effective strategies for preventing the spread of tuberculosis.
How similar studies have gone: While the specific mechanisms of cough in tuberculosis transmission are being explored in this research, similar studies have shown promise in understanding infectious disease transmission dynamics.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Shiloh, Michael — Weill Medical Coll of Cornell Univ
- Study coordinator: Shiloh, Michael
Related research
Other NIH-funded projects on the same topics.
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Understanding and preventing lung problems after tuberculosis treatment
This research aims to find new ways to identify people who are at risk of developing long-term lung issues after completing treatment for tuberculosis.
-
Understanding how tuberculosis bacteria cause cough and spread
This study is looking at how the bacteria that cause tuberculosis can make people cough, which helps them spread the infection, and it aims to find out how this happens so we can better control the disease.
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Identifying patients at risk of lung disease after tuberculosis treatment
This study is looking for ways to help people who have finished their tuberculosis treatment by finding out who might develop lung problems later on, using new tools like a mobile app to track coughs instead of just relying on standard lung tests.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.