Cough control with dexmedetomidine, magnesium sulfate, or lidocaine after general anesthesia
Official title: Comparative Study Between Efficacy of Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression During General Anesthetic Emergence
Run by Al-Azhar University · NCT06979141 · Data updated 2026-11-12
This study will see if dexmedetomidine, magnesium sulfate, or lidocaine reduces how often and how hard adults cough while waking from general anesthesia.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | June 2, 2025 |
| Main results expected | June 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | June 11, 2025 |
| Trial ID | NCT06979141 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21–60 years, ASA physical status I–II, BMI under 30 kg/m2, Mallampati class I–II who are scheduled for surgery under general anesthesia at the Al‑Azhar Assiut center are ideal candidates.
✕Probably not a fit
Patients with major organ disease, active airway infection or prior airway surgery, BMI over 30, pregnant or lactating women, or those taking cough‑inducing medications are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, double-blind Phase 3 trial comparing dexmedetomidine, magnesium sulfate, and lidocaine to normal saline for cough suppression during emergence from general anesthesia. Eligible adults (21–60 years) with ASA I–II and BMI <30 undergoing surgery under general anesthesia are randomized to one of the study arms and managed by blinded staff. The number and severity of coughs during emergence are recorded as primary outcomes, with monitoring for hemodynamic and respiratory side effects. The trial is conducted at the Faculty of Medicine, Al‑Azhar University, Assiut, Egypt.
Why it matters
Potential benefit: If effective, one of these drugs could reduce coughing and related complications during recovery from general anesthesia, resulting in a smoother and safer emergence.
How similar studies have gone: Prior smaller trials have shown intravenous dexmedetomidine and lidocaine can reduce emergence coughing, while evidence for magnesium sulfate in this setting is more limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 21-60 years. * Both genders. * Body mass index \< 30 kg/ m2 * American Society of Anesthesiology (ASA) physical status I-II. * Mallampati score class I or II. * Patients undergoing surgery under general anesthesia. Exclusion Criteria: * Known allergy to study drugs. * History of psychiatric illness. * Patients with major organ diseases. * Pre-existing neurological deficits. * Body mass index \>30 kg/m2. * Active airway infection or history of tracheal and laryngeal surgery. * Lower esophageal sphincter incompetence (and reflux). * Increased intracranial and intraocular pressure. * Use of cough-inducing medications * Pregnant, and lactating women.
Where it's running
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Faculty of Medicine, Al-Azhar university Assiut, Egypt.
Asyut, Egypt Recruiting
Study contacts
- Principal investigator: Mahmoud T Abd Elhafeez, Specialist.Mcs — mahmoud.talaat750@gmail.com
- Study coordinator: Medhat H Allam, lecturer.MD
- Email: Medhathelaly@gmail.com
- Phone: 1003012989
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.