Radicle GI Health VNB: A test of health and wellness products for constipation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled, direct-to-consumer study conducted in the United States. Adult participants will use a GI health product or placebo for five weeks, with electronic self-reports collected throughout. The trial requires a minimum of 30% improvement in a primary health outcome and excludes individuals with pregnancy, heavy drinking, certain medications, or other safety concerns. No in-person visits are involved, and all data are captured electronically in a real-world setting. The aim is to see if the active product provides better constipation-related health outcomes than placebo.

Why it matters

Who can join: the full rules

3.1 Inclusion

Participants must meet all the following criteria:

* Adults, at least 21 years of age at the time of electronic consent, inclusive of all ethnicities, races, and gender identities

  * Assigned sex at birth will determine sex-specific recruitment and PROs (male vs female) employed, when needed
* Resides in the United States
* Has the opportunity for at least 30% improvement in their primary health outcome
* Expresses a willingness to take a study product and not know the product identity (active or placebo) until the end of the study

3.2 Exclusion

Individuals who report any of the following during screening may be excluded from participation:

* Report being pregnant, trying to become pregnant, or breastfeeding
* Unable to provide a valid US shipping address and mobile phone number
* Reports current enrollment in another clinical trial
* Reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages per day)
* Unable to read and understand English at a 7th grade level
* Reports a current and/or recent (up to 3 months ago) major illness and/or surgery that poses a known, significant safety risk.
* Reports a diagnosis of cardiac dysfunction, liver or kidney disease that presents a known contraindication and/or a significant safety risk with any of the study product ingredients.

  * NYHA Class III or IV congestive heart failure, atrial fibrillation, uncontrolled arrhythmias, cirrhosis, end-stage liver disease, stage 3b or 4 chronic kidney disease, or kidney failure
* Reports taking medications that have a well-established moderate or severe interaction, posing a substantial safety risk with any of the study product ingredients.

  * Anticoagulants, antihypertensives, anxiolytics, antidepressants, chemotherapy, immunotherapy, sedative hypnotics, seizure medications, medications that warn against grapefruit consumption, corticosteroids at doses greater than 5 mg per day, diabetic medications, oral anti-infectives (antibiotics, antifungals, antivirals) to treat an acute infection, antipsychotics, MAOIs, or thyroid products
* Reports current use of the primary ingredient(s) and/or similar product(s) to the active study product(s) that may limit the effects of the study products and/or pose a safety risk

  * Reports taking any product for acute constipation
  * Reports taking any medications containing levodopa
* Lack of reliable daily access to the internet

Where it's running

• Radicle Science Inc.
  Del Mar, California, United States Recruiting

Study contacts

• Principal investigator: Susan Hewlings — Radicle Science
• Study coordinator: Study Manager
• Email: studymgmt@radiclescience.com
• Phone: 858-779-0086

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.