LcS-fermented milk for constipation in Filipino adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–59 with constipation-related symptoms will be enrolled at the University of Santo Tomas and assigned to either a daily LcS probiotic drink or a control group for four weeks. Participants will keep their usual physical activity and consume the study drink once a day while researchers track stool consistency (Bristol Stool Form Scale), stool frequency and duration, and gastrointestinal discomfort. Key exclusions include recent antibiotic use, high-fiber diets, dairy allergy or lactose intolerance, pregnancy, and chronic diseases that could affect results. Outcomes after four weeks in the probiotic group will be compared to the control group to see if there are meaningful differences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Filipino adult male or female aged 18 to 59 years old
* Apparently healthy adults with constipation-related symptoms of hard to lumpy stools (Bristol Stool Form Scale 1-2) in 25% or more of defecations in a week
* With cold storage at home

Exclusion Criteria:

1. Habitual intake of food items containing probiotics and prebiotics as food supplements (previous 3 months, at least three times per week)
2. Constipation due to organic or neurologic origin
3. High fiber intake (\>30 g/day)
4. Pregnant or lactating
5. Allergy to dairy products and/or lactose intolerance
6. Use of laxatives, anticholinergics and medications for constipation or diarrhea within the past three months
7. Use of antibiotics within the past two weeks
8. Presence of chronic diseases such as diabetes mellitus and its complications, cardiovascular diseases, kidney problems
9. GI condition that may interfere with the evaluation of the outcome such as hemorrhoids, intestinal obstruction and inflammatory bowel diseases
10. Recent history of any gastrointestinal surgery
11. Have pre-existing medical conditions like hypo- or hyperthyroidism and congenital abnormalities
12. Participation in another study with test product two months prior the study

Where it's running

• University of Santo Tomas
  Manila, Manila, Philippines Recruiting

Study contacts

• Principal investigator: Diane S MENDOZA-SARMIENTO, Ph.D in Health Research — University of Santo Tomas
• Study coordinator: Diane S Mendoza-Sarmiento, Ph.D
• Email: dsmendoza@ust.edu.ph
• Phone: +639088738336

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.