Understanding constipation in patients with systemic sclerosis
Interrogating the pathophysiological mechanisms of constipation in patients with systemic sclerosis
This study is looking into why people with systemic sclerosis often have constipation, focusing on how their body's nerves and muscles might be affecting their bowel movements, with the goal of finding better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10896425 on NIH RePORTER |
What this research studies
This research investigates the causes of constipation in patients suffering from systemic sclerosis, a condition that can lead to severe gastrointestinal complications. The study aims to identify different physiological mechanisms that contribute to constipation in these patients, including issues with anal muscle relaxation and neural control of bowel function. By examining how autonomic nervous system dysfunction affects colorectal physiology, the research seeks to improve treatment responses for patients experiencing constipation related to systemic sclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with systemic sclerosis who experience significant constipation.
Not a fit: Patients without systemic sclerosis or those who do not experience constipation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for constipation in patients with systemic sclerosis, improving their quality of life.
How similar studies have performed: While the specific mechanisms of constipation in systemic sclerosis are not well-studied, there is emerging evidence suggesting that understanding these mechanisms could lead to significant advancements in treatment.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mcmahan, Zsuzsanna Hortobagyi — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mcmahan, Zsuzsanna Hortobagyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.