Probiotics for constipation in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial is an randomized, double-blind, placebo-controlled study enrolling adults with constipation. Participants are assigned to receive either a probiotic product or a placebo for 8 weeks. Outcomes include measurements from blood and stool samples as well as multidimensional questionnaires to assess gut function, immune status, and mental well-being. The study aims to determine whether probiotic use can improve gastrointestinal symptoms and related health aspects in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 65 years (inclusive).
* Diagnosed with constipation, defined as fewer than 3 spontaneous bowel movements per week and/or Bristol Stool Form Scale types 1 or 2.
* Willing and able to comply with the study protocol and complete all required assessments.
* Provide written informed consent prior to any study-related procedures.
* Male and female participants of childbearing potential must agree to use effective contraception voluntarily from 14 days prior to screening until 6 months after the end of the trial. Female participants of non-childbearing potential (e.g., post-menopausal or surgically sterile) are exempt from this requirement.

Exclusion Criteria:

* Use of products with functions similar to the investigational product within a short period prior to screening that may interfere with the evaluation of study outcomes.
* Intention to change dietary habits significantly during the study period.
* Severe allergies or immunodeficiency.
* Women who are pregnant, breastfeeding, or planning to become pregnant during the trial.
* Severe diseases of vital organs (including cardiovascular, pulmonary, hepatic, or renal disease), metabolic diseases (e.g., diabetes, thyroid disorders), malignancy, or severe immune system disorders.
* Use of antibiotics within the past 30 days.
* Severe psychological or psychiatric disorders.
* Poor compliance (e.g., failure to take the test product as instructed or failure to attend scheduled follow-up visits) that would preclude a valid assessment of efficacy.
* Organic constipation (e.g., caused by structural or pathological conditions).
* Irritable bowel syndrome with constipation (IBS-C).
* History of surgical procedures within 30 days prior to screening that may have caused or contributed to constipation symptoms.
* Intake of probiotic or prebiotic supplements within one month prior to the start of the study.
* Any other condition that, in the investigator's opinion, would make the participant unsuitable for participation in the study.

Where it's running

• Suzhou Ninth People's Hospital
  Suzhou, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Ying Jin, Doctor
• Email: 1959643812@qq.com
• Phone: +86 18336086291

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gut health follow-along with Peachbiotic in adults

  This single-arm study tests whether Peachbiotic taken daily for 12 weeks helps adults with gut symptoms feel better.

  Recruiting Peach Perfect · Las Vegas, Nevada · NCT07927907

• Prebiotic and Probiotic Combo for Constipation Symptoms

  This study tests whether adding 1-kestose to a probiotic (BBH112) helps adults with constipation-related symptoms see more relief and better quality of life.

  Recruiting Seoul National University Hospital · Seongnam-si, Gyeonggi-do · NCT07923279

• Constipation Prevention Checklist in hip surgery patients

  A simple checklist is used to see if hip surgery patients can stay regular by staying hydrated, eating well, moving early, and using abdominal massage.

  Recruiting Cumhuriyet University · Sivas · NCT07895316

• Abdominal massage training for caregivers to help manage constipation

  Caregivers receive training to use abdominal massage and help their loved ones with constipation in palliative care to see if it improves symptoms and caregiver confidence.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07886125

• Relationship between body awareness and posture in IBS-C patients compared with healthy people

  This study tests whether people with constipation-predominant IBS have different interoceptive awareness and posture compared with healthy controls.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07870915

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.