Effects of treating constipation in patients with chronic kidney disease
Official title: Clinical, Biochemical, and Microbiological Effects of Constipation Treatment in Patients with Chronic Kidney Disease: A Pilot Feasibility Trial
Funded at University of Tennessee Health Sci Ctr · NIH-10906180 · Data updated 2026-11-12
This study is looking at how treating constipation might help people with chronic kidney disease feel better and improve their overall health, by checking how laxatives can change gut health and other important health markers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $281,924 |
| NIH project number | 5R01DK135942-02 |
| Project ID | NIH-10906180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic kidney disease who also experience constipation.
✕Less likely to help
Patients with chronic kidney disease who do not experience constipation or have other gastrointestinal disorders unrelated to constipation may not benefit from this research.
What this research studies
This research investigates how treating constipation can impact patients with chronic kidney disease (CKD). It focuses on understanding the relationship between constipation and CKD outcomes, particularly how laxatives may improve gut health and overall clinical conditions. The study will assess changes in gut microbiota, biochemical markers, and clinical outcomes in CKD patients who receive constipation treatment. By exploring these connections, the research aims to provide insights into better management strategies for CKD patients.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for patients with chronic kidney disease by addressing constipation and its associated complications.
How similar studies have gone: While there have been experimental studies in animals showing positive outcomes from constipation treatment in CKD, this research is novel as it aims to evaluate these effects in human patients.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Sumida, Keiichi — University of Tennessee Health Sci Ctr
- Study coordinator: Sumida, Keiichi
Related research
Other NIH-funded projects on the same topics.
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Constipation treatment to improve gut and kidney health in people with chronic kidney disease
This pilot will see if treating constipation improves gut bacteria, blood markers, and overall health in people with chronic kidney disease.
-
Personalized CKD-MBD care using systems biology and AI
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.