Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns
1/2 Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
This study is looking at whether inhaled nitric oxide can help newborns with congenital diaphragmatic hernia during their critical early days after birth, and it aims to gather solid information to help doctors make better treatment decisions for these babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10985924 on NIH RePORTER |
What this research studies
This research investigates the use of inhaled nitric oxide (iNO) for treating congenital diaphragmatic hernia (CDH) in newborns. The study aims to evaluate the effectiveness of iNO during the critical postnatal stabilization phase, addressing the ongoing debate about its benefits despite evidence suggesting it may be ineffective or harmful. By collaborating across multiple institutions, the research seeks to gather robust data to inform clinical practices and improve outcomes for affected infants. The approach includes a pragmatic, multi-center trial design that aims to streamline patient enrollment and enhance the reliability of findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with congenital diaphragmatic hernia, particularly those in the postnatal stabilization phase.
Not a fit: Patients who do not have congenital diaphragmatic hernia or those who are beyond the newborn stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for newborns with congenital diaphragmatic hernia, potentially reducing complications and healthcare costs.
How similar studies have performed: Previous studies on the use of inhaled nitric oxide in similar contexts have shown mixed results, indicating that this research could provide valuable insights into its effectiveness.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Harting, Matthew Tihen — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Harting, Matthew Tihen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.