Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns
Official title: 1/2 Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10985924 · Data updated 2026-11-12
This study is looking at whether inhaled nitric oxide can help newborns with congenital diaphragmatic hernia during their critical early days after birth, and it aims to gather solid information to help doctors make better treatment decisions for these babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2031 |
| Funding year | 2024 |
| Award (this year) | $743,657 |
| NIH project number | 1U24HL166769-01A1 |
| Project ID | NIH-10985924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with congenital diaphragmatic hernia, particularly those in the postnatal stabilization phase.
✕Less likely to help
Patients who do not have congenital diaphragmatic hernia or those who are beyond the newborn stage may not benefit from this research.
What this research studies
This research investigates the use of inhaled nitric oxide (iNO) for treating congenital diaphragmatic hernia (CDH) in newborns. The study aims to evaluate the effectiveness of iNO during the critical postnatal stabilization phase, addressing the ongoing debate about its benefits despite evidence suggesting it may be ineffective or harmful. By collaborating across multiple institutions, the research seeks to gather robust data to inform clinical practices and improve outcomes for affected infants. The approach includes a pragmatic, multi-center trial design that aims to streamline patient enrollment and enhance the reliability of findings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for newborns with congenital diaphragmatic hernia, potentially reducing complications and healthcare costs.
How similar studies have gone: Previous studies on the use of inhaled nitric oxide in similar contexts have shown mixed results, indicating that this research could provide valuable insights into its effectiveness.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Harting, Matthew Tihen — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Harting, Matthew Tihen
Related research
Other NIH-funded projects on the same topics.
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Inhaled Nitric Oxide for Babies with CDH
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
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Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
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Integrating growth models and preclinical data to improve CDH patch repair
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
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Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
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Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
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Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.