Understanding lung development in babies with congenital diaphragmatic hernia
Modeling fetal lung development in congenital diaphragmatic hernia
This work aims to uncover why the lungs of babies with congenital diaphragmatic hernia do not develop properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11169895 on NIH RePORTER |
What this research studies
Congenital diaphragmatic hernia (CDH) is a birth defect where organs from the abdomen move into the chest, preventing the lungs from growing as they should. Despite advanced medical care, many babies with severe CDH still face significant challenges, and we don't fully understand why their lungs are so underdeveloped. This project will create models to explore the basic biological signals that guide lung growth and how they are disrupted in CDH. By focusing on specific pathways like YAP/TAZ and FGF10, we hope to learn more about the underlying causes of poor lung development.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease mechanisms and is not directly recruiting patients for participation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve lung development and outcomes for babies born with congenital diaphragmatic hernia.
How similar studies have performed: While the specific mechanisms of YAP/TAZ and FGF10 in CDH lung hypoplasia are still being explored, these pathways are known to be important in general lung development.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kunisaki, Shaun Michael — Johns Hopkins University
- Study coordinator: Kunisaki, Shaun Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.