Using biodegradable patches to treat congenital diaphragmatic hernia
Official title: Biodegradable elastic patches for congenital diaphragmatic hernia treatment
Funded at University of Texas Arlington · NIH-10667413 · Data updated 2026-11-12
This study is testing new stretchy patches made from biodegradable materials to help treat congenital diaphragmatic hernia in babies, aiming to improve healing and reduce complications as the child grows.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | July 19, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $194,375 |
| NIH project number | 5R21HD107324-02 |
| Project ID | NIH-10667413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and children diagnosed with congenital diaphragmatic hernia requiring surgical intervention.
✕Less likely to help
Patients with congenital diaphragmatic hernia who are not candidates for surgical repair or those with other severe comorbidities may not benefit from this research.
What this research studies
This research focuses on developing biodegradable elastic patches to treat congenital diaphragmatic hernia (CDH), a serious birth defect where abdominal organs move into the chest due to an incomplete diaphragm. The approach involves creating patches that can grow with the child, reducing the risk of complications associated with traditional synthetic materials. By utilizing innovative materials that promote healing and growth, the research aims to improve surgical outcomes for affected children. The project will involve testing these patches in a clinical setting to evaluate their effectiveness and safety.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for children with congenital diaphragmatic hernia.
How similar studies have gone: Previous research has shown promise in using biodegradable materials for surgical applications, indicating potential success for this novel approach.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Hong, Yi — University of Texas Arlington
- Study coordinator: Hong, Yi
Related research
Other NIH-funded projects on the same topics.
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Inhaled Nitric Oxide for Babies with CDH
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
-
Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
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Integrating growth models and preclinical data to improve CDH patch repair
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
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Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
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Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
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Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.