Integrating growth models and preclinical data to improve CDH patch repair
Official title: Integrating Microstructural Growth Models with Preclinical Data to Advance Congenital Diaphragmatic Hernia Patch Repair
Funded at Georgia Institute of Technology · NIH-11373946 · Data updated 2026-11-12
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $438,349 |
| NIH project number | 1R21HD115087-01A1 |
| Project ID | NIH-11373946 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants and young children with congenital diaphragmatic hernia requiring patch repair.
✕Less likely to help
Patients whose CDH is not treated with patches or who do not undergo growth-related patch consideration may not benefit.
What this research studies
Researchers will build a computer model that links how patches behave in growing tissue with data from lab and animal studies. The goal is to predict which patch materials and designs will best hold up as a child grows, guiding surgeons in choosing the right option. This work combines experimental data with simulations to understand patch–tissue dynamics in pediatric CDH repair. The project aims to reduce patch failures and improve long-term outcomes for affected infants.
Why it matters
Potential benefit: If successful, the model could help surgeons pick patches that last longer and fit better as children grow, reducing the need for repeat surgeries.
How similar studies have gone: Previous studies show that integrating modeling with preclinical data can improve material performance predictions, but this project advances toward pediatric CDH-specific growth dynamics.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Ramaraju, Sriharsha — Georgia Institute of Technology
- Study coordinator: Ramaraju, Sriharsha
Related research
Other NIH-funded projects on the same topics.
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Inhaled Nitric Oxide for Babies with CDH
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
-
Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
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Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
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Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
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Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
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Understanding lung development in babies with congenital diaphragmatic hernia
This work aims to uncover why the lungs of babies with congenital diaphragmatic hernia do not develop properly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.