Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
Official title: 1/2 Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11261516 · Data updated 2026-11-12
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2032 |
| Funding year | 2026 |
| Award (this year) | $697,451 |
| NIH project number | 5U24HL166769-02 |
| Project ID | NIH-11261516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants diagnosed with congenital diaphragmatic hernia who require postnatal stabilization and are treated at participating centers.
✕Less likely to help
Babies not treated at participating sites or those outside the postnatal stabilization window may not benefit.
What this research studies
This project brings together several hospitals to study a common problem in babies born with diaphragmatic hernia. It uses a practical, real-world approach to change how care is delivered in the first days of life, aiming to reduce unnecessary treatments and costs. The study design is stepped-wedge and cluster-randomized to compare current practice with a streamlined care path across sites. Data from participating babies will be collected to understand outcomes and guide future clinical decisions. The goal is to improve stability and survival while avoiding ineffective or harmful interventions.
Why it matters
Potential benefit: If successful, this work could simplify early care for newborns with CDH and reduce exposure to ineffective treatments, potentially improving outcomes and lowering costs.
How similar studies have gone: Previous CDH trials faced enrollment and power challenges, but a collaborative, pragmatic design aims to produce clearer evidence for practice.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Harting, Matthew Tihen — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Harting, Matthew Tihen
Related research
Other NIH-funded projects on the same topics.
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Inhaled Nitric Oxide for Babies with CDH
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
-
Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
-
Integrating growth models and preclinical data to improve CDH patch repair
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
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Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
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Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
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Understanding lung development in babies with congenital diaphragmatic hernia
This work aims to uncover why the lungs of babies with congenital diaphragmatic hernia do not develop properly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.