Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns
Official title: Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Funded at University of Tennessee Health Sci Ctr · NIH-10985923 · Data updated 2026-11-12
This study is looking at how well inhaled nitric oxide helps newborns with congenital diaphragmatic hernia, a condition that affects their lungs, to see if it can improve their health and make a difference in their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $915,604 |
| NIH project number | 1UG3HL166767-01A1 |
| Project ID | NIH-10985923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with congenital diaphragmatic hernia who require postnatal stabilization.
✕Less likely to help
Patients with congenital diaphragmatic hernia who are not eligible for inhaled nitric oxide treatment or those with other severe comorbidities may not benefit from this research.
What this research studies
This research investigates the effectiveness of inhaled nitric oxide (iNO) in stabilizing newborns with congenital diaphragmatic hernia (CDH), a serious condition affecting lung development. The study involves multiple medical centers and aims to gather data on the clinical outcomes of using iNO in these patients. By comparing outcomes in a structured manner, the research seeks to determine whether iNO is beneficial or potentially harmful, addressing a significant gap in current clinical practice. The approach is designed to streamline the process of evaluating treatment effectiveness while minimizing resource use.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for newborns with congenital diaphragmatic hernia, potentially reducing complications and healthcare costs.
How similar studies have gone: Previous research has indicated that inhaled nitric oxide may be ineffective for CDH, but this study aims to rigorously evaluate its use in a larger, multi-center setting, making it a novel approach.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Jancelewicz, Timothy — University of Tennessee Health Sci Ctr
- Study coordinator: Jancelewicz, Timothy
Related research
Other NIH-funded projects on the same topics.
-
Inhaled Nitric Oxide for Babies with CDH
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
-
Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
-
Integrating growth models and preclinical data to improve CDH patch repair
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
-
Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
-
Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
-
Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.