Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns
Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
This study is looking at how well inhaled nitric oxide helps newborns with congenital diaphragmatic hernia, a condition that affects their lungs, to see if it can improve their health and make a difference in their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10985923 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of inhaled nitric oxide (iNO) in stabilizing newborns with congenital diaphragmatic hernia (CDH), a serious condition affecting lung development. The study involves multiple medical centers and aims to gather data on the clinical outcomes of using iNO in these patients. By comparing outcomes in a structured manner, the research seeks to determine whether iNO is beneficial or potentially harmful, addressing a significant gap in current clinical practice. The approach is designed to streamline the process of evaluating treatment effectiveness while minimizing resource use.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with congenital diaphragmatic hernia who require postnatal stabilization.
Not a fit: Patients with congenital diaphragmatic hernia who are not eligible for inhaled nitric oxide treatment or those with other severe comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for newborns with congenital diaphragmatic hernia, potentially reducing complications and healthcare costs.
How similar studies have performed: Previous research has indicated that inhaled nitric oxide may be ineffective for CDH, but this study aims to rigorously evaluate its use in a larger, multi-center setting, making it a novel approach.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Jancelewicz, Timothy — University of Tennessee Health Sci Ctr
- Study coordinator: Jancelewicz, Timothy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.