Inhaled Nitric Oxide for Babies with CDH
Official title: Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Funded at University of Tennessee Health Sci Ctr · NIH-11397198 · Data updated 2026-11-12
A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 17, 2024 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $783,237 |
| NIH project number | 4UH3HL166767-02 |
| Project ID | NIH-11397198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants with congenital diaphragmatic hernia treated at participating centers, enrolled during the trial period.
✕Less likely to help
Some infants may not experience better outcomes and could face adjustments in their treatment plans.
What this research studies
This project tests a real-world approach to treating babies born with congenital diaphragmatic hernia by removing a common practice (inhaled nitric oxide) and using a stepped-wedge design across centers. Researchers will analyze patient outcomes during a pragmatic rollout to see if withholding iNO changes survival, organ function, and hospital resources. The study builds on a long-standing CDH collaboration to learn quickly from multiple sites while prioritizing patient safety and practical logistics. Results could guide future standards of care for newborns with CDH and reduce unnecessary treatment costs.
Why it matters
Potential benefit: If successful, it could streamline postnatal care for babies with CDH and reduce ineffective or costly treatments.
How similar studies have gone: Previous CDH trials faced enrollment and power challenges, but collaborative designs have shown value when executed efficiently.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Jancelewicz, Timothy — University of Tennessee Health Sci Ctr
- Study coordinator: Jancelewicz, Timothy
Related research
Other NIH-funded projects on the same topics.
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Fetal tracheal aspirates to guide CDH therapies and timing for lung growth
A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.
-
Integrating growth models and preclinical data to improve CDH patch repair
A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.
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Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia
Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.
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Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia
This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.
-
Finding genes that cause congenital diaphragmatic hernia
This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.
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Understanding lung development in babies with congenital diaphragmatic hernia
This work aims to uncover why the lungs of babies with congenital diaphragmatic hernia do not develop properly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.