Identifying genes linked to congenital diaphragmatic hernia
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
This study is trying to find out which genes are linked to congenital diaphragmatic hernia to help improve how we diagnose and treat this birth defect.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Sex | All |
| Sponsor | Columbia University Academic / other |
| Locations | 14 sites (Chicago, Illinois and 13 other locations) |
| Trial ID | NCT00950118 on ClinicalTrials.gov |
What this trial studies
This study aims to identify genetic factors that contribute to congenital diaphragmatic hernia (CDH), a birth defect where the diaphragm does not form properly. By examining the genes of affected individuals and their families, researchers hope to uncover the molecular mechanisms behind CDH. The study will focus on understanding the inheritance patterns and potential environmental influences that may lead to this condition. Ultimately, the findings could enhance diagnosis, prevention, and treatment strategies for CDH.
Who should consider this trial
Good fit: Ideal candidates include individuals with congenital diaphragmatic hernia or those with a family history of the condition.
Not a fit: Patients without a personal or family history of congenital diaphragmatic hernia may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for congenital diaphragmatic hernia.
How similar studies have performed: Other studies have shown promise in identifying genetic factors related to congenital anomalies, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All individuals affected with a congenital diaphragmatic hernia (CDH), or with a family history of a CDH Exclusion Criteria: * Individuals with no personal history of a CDH or family history of a family member affected with congenital diaphragmatic hernia
Where this trial is running
Chicago, Illinois and 13 other locations
- Rush Hospital — Chicago, Illinois, United States (Recruiting)
- University of Michigan/ CS Mott Children's Hospital — Ann Arbor, Michigan, United States (Recruiting)
- Washington University Medical Center/ St. Louis Children's Hospital — St Louis, Missouri, United States (Recruiting)
- Children's Hospital of Omaha/ University of Nebraska — Omaha, Nebraska, United States (Recruiting)
- Northwell Health — Manhasset, New York, United States (Recruiting)
- New York University, Hassenfeld Children's Hospital at NYU Langone Health — New York, New York, United States (Recruiting)
- Morgan Stanley Children's Hospital of New York- Presbyterian (Columbia University Medical Center) — New York, New York, United States (Recruiting)
- Cincinnati Children's Hospital and Medical Center/ University of Cincinnati — Cincinnati, Ohio, United States (Recruiting)
- Oregon Health & Science University, Doernbecher Children's Hospital — Portland, Oregon, United States (Recruiting)
- Children's Hospital of Pittsburgh/ University of Pittsburgh — Pittsburgh, Pennsylvania, United States (Recruiting)
- Monroe Carrell Jr Children's Hospital at Vanderbilt — Nashville, Tennessee, United States (Completed)
- UT Southwestern Medical Center, Children's Health, Dallas — Dallas, Texas, United States (Recruiting)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Completed)
- Cairo University Hospital — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Yufeng Shen, PhD — Columbia University
- Study coordinator: Anah Kim Hetzler
- Email: ak3578@columbia.edu
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.