Identifying genes linked to congenital diaphragmatic hernia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify genetic factors that contribute to congenital diaphragmatic hernia (CDH), a birth defect where the diaphragm does not form properly. By examining the genes of affected individuals and their families, researchers hope to uncover the molecular mechanisms behind CDH. The study will focus on understanding the inheritance patterns and potential environmental influences that may lead to this condition. Ultimately, the findings could enhance diagnosis, prevention, and treatment strategies for CDH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All individuals affected with a congenital diaphragmatic hernia (CDH), or with a family history of a CDH

Exclusion Criteria:

* Individuals with no personal history of a CDH or family history of a family member affected with congenital diaphragmatic hernia

Where it's running

• Rush Hospital
  Chicago, Illinois, United States Recruiting
• University of Michigan/ CS Mott Children's Hospital
  Ann Arbor, Michigan, United States Recruiting
• Washington University Medical Center/ St. Louis Children's Hospital
  St Louis, Missouri, United States Recruiting
• Children's Hospital of Omaha/ University of Nebraska
  Omaha, Nebraska, United States Recruiting
• Northwell Health
  Manhasset, New York, United States Recruiting
• New York University, Hassenfeld Children's Hospital at NYU Langone Health
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Yufeng Shen, PhD — Columbia University
• Study coordinator: Anah Kim Hetzler
• Email: ak3578@columbia.edu

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• FETO with a Goldballoon device for fetuses with diaphragmatic hernia

  This study tests whether performing Fetoscopic Endoluminal Tracheal Occlusion on pregnancies with fetal diaphragmatic hernia improves baby survival and reduces long-term problems.

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• Fetal tracheal occlusion (FETO) for severe congenital diaphragmatic hernia

  This trial will test whether fetal endoluminal tracheal occlusion (FETO) helps fetuses with severe congenital diaphragmatic hernia and intrathoracic liver herniation survive to hospital discharge.

  Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07187206

• Long-term outcomes after FETO for severe left or right congenital diaphragmatic hernia

  This trial will test whether performing FETO in fetuses with isolated severe left or right CDH helps more babies survive to hospital discharge and have fewer long-term problems than standard care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07166172

• Fetal treatment for congenital diaphragmatic hernia

  This study is testing a new way to treat congenital diaphragmatic hernia in unborn babies by placing a balloon in their airway to help their lungs grow before they are born.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06884423

• Fetoscopic balloon (FETO) for severe left and right congenital diaphragmatic hernia — long-term outcomes

  This trial will try placing and later removing a tiny balloon in the fetal windpipe around 27–29 weeks to help babies with severe congenital diaphragmatic hernia and liver herniation survive the newborn period.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06739356

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.