Physiological umbilical cord clamping for newborns with congenital diaphragmatic hernia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of physiological umbilical cord clamping in newborns diagnosed with congenital diaphragmatic hernia (CDH). The study aims to compare this method to immediate post-intubation clamping to assess its impact on reducing hypoxia and improving cardiac output. Conducted at Garrahan Children's Hospital, the trial will involve randomized participants who meet specific inclusion criteria, including a prenatal diagnosis of CDH and a gestational age of over 34 weeks. The study will also evaluate patient evolution and maternal outcomes within 24 hours post-birth.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Prenatal diagnosis of congenital diaphragmatic hernia
* gestational age \>34 weeks
* Informed consent signed by the patient's parents

Exclusion Criteria:

* Multiple gestation
* Major malformation or fetal genetic anomaly diagnosed in the prenatal stage
* Emergency cesarean section or maternal condition that prevents the approach
* Lack of informed consent

Where it's running

• Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan"
  Buenos Aires, Argentina Recruiting

Study contacts

• Principal investigator: Mariela Jozefkowicz — Hospital JP Garrahan
• Study coordinator: Mariela Jozefkowicz
• Email: mjozefkowicz@garrahan.gov.ar
• Phone: +5491164646270

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• FETO with a Goldballoon device for fetuses with diaphragmatic hernia

  This study tests whether performing Fetoscopic Endoluminal Tracheal Occlusion on pregnancies with fetal diaphragmatic hernia improves baby survival and reduces long-term problems.

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• Fetal tracheal occlusion (FETO) for severe congenital diaphragmatic hernia

  This trial will test whether fetal endoluminal tracheal occlusion (FETO) helps fetuses with severe congenital diaphragmatic hernia and intrathoracic liver herniation survive to hospital discharge.

  Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07187206

• Long-term outcomes after FETO for severe left or right congenital diaphragmatic hernia

  This trial will test whether performing FETO in fetuses with isolated severe left or right CDH helps more babies survive to hospital discharge and have fewer long-term problems than standard care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07166172

• Fetal treatment for congenital diaphragmatic hernia

  This study is testing a new way to treat congenital diaphragmatic hernia in unborn babies by placing a balloon in their airway to help their lungs grow before they are born.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06884423

• Fetoscopic balloon (FETO) for severe left and right congenital diaphragmatic hernia — long-term outcomes

  This trial will try placing and later removing a tiny balloon in the fetal windpipe around 27–29 weeks to help babies with severe congenital diaphragmatic hernia and liver herniation survive the newborn period.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06739356

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.