Understanding how metronidazole resistance affects Clostridium difficile infections.
Official title: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection.
Funded at Texas A&m University Health Science Ctr · NIH-11014389 · Data updated 2026-11-12
This study is looking into why some Clostridium difficile infections don't respond to a common treatment called metronidazole, and it aims to help patients by figuring out how these resistant strains work so doctors can find better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | August 20, 2018 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $744,973 |
| NIH project number | 5R01AI139261-07 |
| Project ID | NIH-11014389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with Clostridium difficile infections, particularly those infected with resistant strains.
✕Less likely to help
Patients who do not have Clostridium difficile infections or those with infections caused by non-resistant strains may not benefit from this research.
What this research studies
This research investigates the growing problem of Clostridium difficile infections (CDI), particularly focusing on how certain strains have developed resistance to metronidazole, a common treatment. The study aims to analyze the genetic factors contributing to this resistance and how it impacts patient outcomes. By examining clinical data and conducting genome analyses, researchers hope to uncover the mechanisms behind the resistance and its implications for treatment strategies. Patients may benefit from improved understanding and management of CDI as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved outcomes for patients suffering from Clostridium difficile infections.
How similar studies have gone: Previous research has shown that understanding antibiotic resistance mechanisms can lead to significant advancements in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Hurdle, Julian G — Texas A&m University Health Science Ctr
- Study coordinator: Hurdle, Julian G
Related research
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How new antibiotic resistance in C. difficile affects treatment
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-
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This study is trying to find out how certain body factors, like gut bacteria and genetics, affect the chances of Clostridioides difficile infection coming back in adults who have already been diagnosed with it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.