Investigating Clostridium difficile infections in patients with inflammatory bowel disease
Official title: Understanding Clostridium difficile Infection in Patients with inflammatory Bowel Disease
Funded at Brigham and Women's Hospital · NIH-10774228 · Data updated 2026-11-12
This study is looking at how Clostridium difficile infections can impact people with inflammatory bowel disease, aiming to find out why these infections happen more often and come back in these patients, so we can improve their treatment and care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $196,358 |
| NIH project number | 5K23DK120898-05 |
| Project ID | NIH-10774228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with inflammatory bowel disease who have experienced or are at risk for Clostridium difficile infections.
✕Less likely to help
Patients without inflammatory bowel disease or those who have not experienced Clostridium difficile infections may not benefit from this research.
What this research studies
This research focuses on understanding how Clostridium difficile infections (CDI) affect patients with inflammatory bowel disease (IBD). It aims to identify the mechanisms behind the increased risk and recurrence of CDI in IBD patients, particularly how changes in bile acids may influence infection outcomes. The study will utilize various methodologies to assess risk factors and improve treatment strategies for those at high risk of recurrent infections. By better understanding these dynamics, the research seeks to enhance patient care and management.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of IBD patients at risk for recurrent CDI, potentially reducing disease flares and the need for colectomy.
How similar studies have gone: Other research has shown success in understanding CDI in general populations, but this specific focus on IBD patients is relatively novel and untested.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Allegretti, Jessica R. — Brigham and Women's Hospital
- Study coordinator: Allegretti, Jessica R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.