A new antiviral medicine for chronic hepatitis B that aims for a complete cure
Official title: Development of a host-targeted antiviral as a chronic hepatitis B therapeutic with potential to achieve a functional cure
Funded at Evrys Bio, LLC · NIH-11141017 · Data updated 2026-11-12
This project is creating a new medicine to help people with chronic hepatitis B achieve a lasting cure, rather than just controlling the infection.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Evrys Bio, LLC NIH-funded |
| Lab location | 1 site (Doylestown, United States) |
| Project start | August 20, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $961,797 |
| NIH project number | 5R44AI157725-03 |
| Project ID | NIH-11141017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic hepatitis B infection who currently rely on treatments that only control the virus would be the ideal candidates for this future therapy.
✕Less likely to help
Patients without chronic hepatitis B infection or those whose condition is already fully resolved would not benefit from this specific treatment.
What this research studies
Chronic hepatitis B can lead to serious liver problems, and current treatments often don't fully get rid of the virus. This project is working on a new type of antiviral medicine that targets a specific part of the body's own cells, called sirtuins, to fight the hepatitis B virus. Researchers believe this approach could lead to a "functional cure," meaning the virus would become undetectable and inactive in the body. The initial steps involve confirming how well this new medicine works in human liver cells and against different types of the virus.
Why it matters
Potential benefit: If successful, this medicine could offer a lasting cure for chronic hepatitis B, preventing severe liver disease for millions of people worldwide.
How similar studies have gone: The applicant has previously identified sirtuin modulators with broad antiviral activity, suggesting a promising, though still early-stage, approach.
Where this research is happening
-
Evrys Bio, LLC
Doylestown, United States Active
Researchers
- Principal investigator: Remiszewski, Stacy — Evrys Bio, LLC
- Study coordinator: Remiszewski, Stacy
Related research
Other NIH-funded projects on the same topics.
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HBV immune responses in functional cure and therapies guided by CD4 T cells and B cells
This grant studies how HBV-specific CD4 T cells and B cells behave in people with hepatitis B to identify clues for achieving a functional cure.
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Therapeutic nucleic acid vaccine for chronic hepatitis B in people with HIV/HBV co-infection
A new genetic vaccine approach is being tested to help people living with both HIV and chronic hepatitis B reduce and potentially cure their HBV infection.
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HBV immune responses and pathways linked to functional cure
Researchers will study how HBV-specific CD4 T cells and B cells behave in people with chronic hepatitis B to find what immune changes are needed for a functional cure.
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Nanobodies to help clear HBV surface antigen and restore immunity
A small, targeted antibody therapy using nanobodies is being explored to lower hepatitis B surface antigen in people with chronic HBV, with the goal of helping the immune system clear the infection.
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How immune cells help control chronic hepatitis B
This research looks at how two immune cell types (CD4 T cells and B cells) in adults with hepatitis B act differently in people who clear the virus versus those with long-term infection to find clues for treatments that could lead to a functional cure.
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Host-targeted antiviral to achieve a functional cure for chronic hepatitis B
A research project tests a new drug strategy that aims to clear signs of hepatitis B in people who have a chronic infection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.