Developing a new treatment to potentially cure chronic hepatitis B
Development of a host-targeted antiviral as a chronic hepatitis B therapeutic with potential to achieve a functional cure
This study is testing a new type of medicine that targets the hepatitis B virus to help people with chronic hepatitis B by potentially lowering the virus levels in their bodies and improving their health.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Evrys Bio, LLC NIH-funded |
| Lab location | 1 site (Doylestown, United States) |
| Project ID | NIH-11049505 on NIH RePORTER |
What this research studies
This research aims to create a therapeutic approach that targets the hepatitis B virus (HBV) to achieve a functional cure, meaning it could lead to sustained undetectable levels of the virus in the body. The researchers are focusing on a specific family of enzymes called sirtuins, which have shown promise in blocking HBV replication in laboratory settings. By testing a new class of drugs known as SIRT2 inhibitors, the study will evaluate their effectiveness in reducing viral markers in infected liver cells. If successful, this treatment could significantly improve the lives of those living with chronic hepatitis B.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic hepatitis B infection.
Not a fit: Patients who do not have chronic hepatitis B or those with acute hepatitis B may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a functional cure for chronic hepatitis B, reducing the risk of severe liver complications.
How similar studies have performed: Previous research has shown promise in targeting sirtuins for antiviral effects, indicating potential success for this novel approach.
Where this research is happening
Doylestown, United States
- Evrys Bio, LLC — Doylestown, United States (Active)
Researchers
- Principal investigator: Remiszewski, Stacy — Evrys Bio, LLC
- Study coordinator: Remiszewski, Stacy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.