Developing a new treatment to potentially cure chronic hepatitis B
Official title: Development of a host-targeted antiviral as a chronic hepatitis B therapeutic with potential to achieve a functional cure
Funded at Evrys Bio, LLC · NIH-11049505 · Data updated 2026-11-12
This study is testing a new type of medicine that targets the hepatitis B virus to help people with chronic hepatitis B by potentially lowering the virus levels in their bodies and improving their health.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Evrys Bio, LLC NIH-funded |
| Lab location | 1 site (Doylestown, United States) |
| Project start | August 20, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $961,797 |
| NIH project number | 4R44AI157725-02 |
| Project ID | NIH-11049505 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic hepatitis B infection.
✕Less likely to help
Patients who do not have chronic hepatitis B or those with acute hepatitis B may not benefit from this research.
What this research studies
This research aims to create a therapeutic approach that targets the hepatitis B virus (HBV) to achieve a functional cure, meaning it could lead to sustained undetectable levels of the virus in the body. The researchers are focusing on a specific family of enzymes called sirtuins, which have shown promise in blocking HBV replication in laboratory settings. By testing a new class of drugs known as SIRT2 inhibitors, the study will evaluate their effectiveness in reducing viral markers in infected liver cells. If successful, this treatment could significantly improve the lives of those living with chronic hepatitis B.
Why it matters
Potential benefit: If successful, this research could provide a functional cure for chronic hepatitis B, reducing the risk of severe liver complications.
How similar studies have gone: Previous research has shown promise in targeting sirtuins for antiviral effects, indicating potential success for this novel approach.
Where this research is happening
-
Evrys Bio, LLC
Doylestown, United States Active
Researchers
- Principal investigator: Remiszewski, Stacy — Evrys Bio, LLC
- Study coordinator: Remiszewski, Stacy
Related research
Other NIH-funded projects on the same topics.
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HBV immune responses in functional cure and therapies guided by CD4 T cells and B cells
This grant studies how HBV-specific CD4 T cells and B cells behave in people with hepatitis B to identify clues for achieving a functional cure.
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Therapeutic nucleic acid vaccine for chronic hepatitis B in people with HIV/HBV co-infection
A new genetic vaccine approach is being tested to help people living with both HIV and chronic hepatitis B reduce and potentially cure their HBV infection.
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HBV immune responses and pathways linked to functional cure
Researchers will study how HBV-specific CD4 T cells and B cells behave in people with chronic hepatitis B to find what immune changes are needed for a functional cure.
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A small, targeted antibody therapy using nanobodies is being explored to lower hepatitis B surface antigen in people with chronic HBV, with the goal of helping the immune system clear the infection.
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How immune cells help control chronic hepatitis B
This research looks at how two immune cell types (CD4 T cells and B cells) in adults with hepatitis B act differently in people who clear the virus versus those with long-term infection to find clues for treatments that could lead to a functional cure.
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Host-targeted antiviral to achieve a functional cure for chronic hepatitis B
A research project tests a new drug strategy that aims to clear signs of hepatitis B in people who have a chronic infection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.