Stopping antiviral treatment for chronic hepatitis B patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify chronic hepatitis B (CHB) patients who can safely discontinue nucleos(t)ide analogues (NAs) while maintaining satisfactory clinical outcomes, such as sustained viral remission and HBsAg clearance. It involves comparing the effects of stopping NAs versus continuing treatment in patients who have been stable on NAs for over a year and a half. The study will assess the potential benefits of treatment cessation based on previous findings that suggest increased HBsAg clearance rates after stopping NAs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. HBsAg positive, HBeAg negative, antibody to HBeAg-positive;
2. Stable administration of anti-HBV neucleos(t)ides analogue mono therapy for at least more than one and a half year;
3. Demonstration of undetectable HBV DNA on three occasions, each at least 6 months apart, which is consistent with the APASL stopping rule;
4. Patients read, understand the consent form, and signed the study consent.

Exclusion Criteria:

1. Patient with other liver diseases;
2. Patient with concurrent hepatitis viruses or HIV infection;
3. Patients are reluctant to stop their anti-HBV treatment.

Where it's running

• Humanity & Health Research Centre
  Hong Kong, Hong Kong SAR, Hong Kong Recruiting

Study contacts

• Study coordinator: George Lau, MD
• Email: gkklau@netvigator.com
• Phone: 852-28613777

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.