Understanding how certain proteins influence brain cancer spread
Official title: Investigating the Role of the ABL Kinase regulated HIF-1a-TAZ Signaling Pathway in the Promotion of Brain Metastasis
Funded at Duke University · NIH-11070241 · Data updated 2026-11-12
This study is looking at how certain proteins help triple-negative breast cancer spread to the brain, with the goal of finding new ways to treat this condition and improve outcomes for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $45,143 |
| NIH project number | 1F31CA290692-01A1 |
| Project ID | NIH-11070241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with triple-negative breast cancer who have developed brain metastases.
✕Less likely to help
Patients with brain metastases from other types of cancer or those without brain metastases may not benefit from this research.
What this research studies
This research investigates the mechanisms behind brain metastasis, particularly focusing on how the ABL kinase and HIF-1α proteins interact to promote the spread of triple-negative breast cancer to the brain. By studying these interactions, the research aims to uncover new therapeutic targets that could lead to more effective treatments for brain metastases. The approach includes analyzing patient samples and utilizing laboratory techniques to understand the signaling pathways involved in cancer progression. Patients may benefit from insights that could lead to novel therapies designed to overcome the challenges posed by brain metastases.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve outcomes for patients with brain metastases from breast cancer.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this area.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Thrash, Hannah Lynn — Duke University
- Study coordinator: Thrash, Hannah Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.