Understanding how small cell lung cancer spreads to the brain

Who could benefit from this research

What this research studies

This research investigates the biological processes that allow small cell lung cancer (SCLC) to metastasize to the brain, a common and serious complication for patients. By using advanced pre-clinical models, the study aims to uncover how SCLC cells adapt and interact with brain cells, which may help them grow in this environment. The research focuses on specific molecular mechanisms, particularly the role of a transcription factor called NFIB, which influences the behavior of cancer cells. Patients may benefit from insights gained that could lead to new treatment strategies targeting brain metastases.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Hartmann, Griffin Gray — Stanford University
• Study coordinator: Hartmann, Griffin Gray

Related research

Other NIH-funded projects on the same topics.

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  This study is looking at how certain changes in lung cancer cells might help the cancer spread to the brain and resist treatments, with the goal of finding new ways to help patients with non-small cell lung cancer.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10842249

• Understanding what makes small cell lung cancer spread using human stem cells

  Researchers will use lung cells made from human stem cells and advanced genetic and sequencing tools to find what causes small cell lung cancer to spread, aiming to help people with SCLC.

  NIH research University of Chicago · Chicago, United States · NIH-11267980

• Targeting a newly discovered cancer stem cell driver that helps non-small cell lung cancer spread

  This project will test whether blocking a newly found regulator in cancer stem cells can slow progression and spread of non-small cell lung cancer.

  NIH research Duke University · Durham, United States · NIH-11258495

• Understanding how lung cancer cells work together to spread

  This research aims to understand how groups of lung cancer cells communicate and move together, which causes cancer to spread throughout the body.

  NIH research Emory University · Atlanta, United States · NIH-11169075

• Understanding how small cell lung cancer spreads

  This study is looking at how small cell lung cancer spreads aggressively by creating special lung cells from human stem cells, so researchers can better understand what makes the cancer grow and spread, helping to improve treatment for patients like you.

  NIH research University of Chicago · Chicago, United States · NIH-11111783

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.