Investigating how radiation and inflammation affect brain tumor growth.
Official title: Studying the Effects of Radiation and Systemic Inflammation on Microglia Contribution to Brain Metastasis Outgrowth
Funded at Ut Southwestern Medical Center · NIH-11069934 · Data updated 2026-11-12
This study looks at how brain tumors and the immune system work together, especially focusing on important brain cells, to see how radiation therapy affects them and how they respond to inflammation, with the goal of finding better treatment options for people with brain metastasis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $39,959 |
| NIH project number | 1F31CA298790-01 |
| Project ID | NIH-11069934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with brain metastasis who are undergoing radiation therapy.
✕Less likely to help
Patients with primary brain tumors or those not receiving radiation therapy may not benefit from this research.
What this research studies
This research explores the complex interactions between brain tumors and the immune system, particularly focusing on glial cells, which are crucial for brain health. It examines how radiation therapy, often the first treatment for brain metastasis, impacts these cells and their response to systemic inflammation. By studying the behavior of microglia and other immune cells in response to radiation and inflammation, the research aims to uncover mechanisms that could influence treatment outcomes for patients with brain metastasis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with brain metastasis, enhancing their response to radiation therapy.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in cancer treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Fross, Shaneann — Ut Southwestern Medical Center
- Study coordinator: Fross, Shaneann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.