ePRO in advanced lung cancer: emotional distress, brain metastasis, and symptom burden

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients with advanced lung cancer, with or without brain metastases, to track emotional distress and symptom burden during first-line and maintenance treatment. It uses patient-reported outcomes collected over time to identify symptom clusters and how these change longitudinally. The study also examines how brain metastasis status relates to emotional distress and symptom trajectories. Participants are divided into three cohorts (no brain metastasis, stable brain metastasis, progressive brain metastasis) and compared on symptom patterns and their correlations with brain metastasis. Analyses focus on descriptive trajectories and subgroup differences to improve understanding of symptom experiences in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Non-brain metastasis cohort: patients with stage IV non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) confirmed by pathology and imaging, without brain metastasis; Brain metastasis cohort: patients with pathologically and radiologically confirmed stage IV NSCLC and SCLC accompanied by brain metastasis;
2. Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2;
3. Age ≥ 18 years old;
4. Estimated survival time ≥ 3 months;
5. Capable and willing to repeatedly complete electronic questionnaires via smartphones or tablets;
6. All enrolled patients signed the hospital-approved informed consent form.

Exclusion Criteria:

1. Prior receipt of anti-tumor treatment;
2. Complicated with severe chronic diseases of the heart, liver, kidney and other vital organs;
3. Abnormal consciousness or mental status;
4. Inability to understand the research content and requirements;
5. A previous medical history of other malignant tumors.

Where it's running

• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Hubei, Wuhan, China Recruiting

Study contacts

• Study coordinator: Qian chu Qian chu, Doctor of Medicine
• Email: qchu@hust.edu.cn
• Phone: 027-69378806

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• What causes vulnerability in older adults with serious diseases and how it affects care decisions

  This study tests how often vulnerability factors appear in older adults with serious illnesses and how these factors influence treatment timing, survival, and quality of life.

  Recruiting Tampere University Hospital · Tampere · NCT07740239

• Urine VOC Test to Detect Lung Cancer in Never Smokers

  A urine test that looks for volatile compounds is tested to see if it can help detect lung cancer in adults who have never smoked.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07871656

• SI-B036 safety test in advanced and metastatic solid tumors

  This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.

  Recruiting at 4 sites Phase 1 SystImmune Inc. · New Haven, Connecticut and 6 other locations · NCT07857616

• Guaraná Supplement for Cancer-Related Fatigue in People Undergoing Treatment

  This study tests whether taking guaraná capsules helps reduce cancer-related fatigue and improve quality of life in adults with breast, lung, colorectal, or gastric cancer who are actively receiving treatment.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá, Bogota D.C. · NCT07816263

• ENPP1/cGAS and FAP in Solid Tumors in Vietnamese Patients

  This Vietnam-based study will test ENPP1, cGAS, and FAP expression in archived tumor samples from Vietnamese adults with solid cancers using immunohistochemistry.

  Recruiting at 2 sites Tam Anh Research Institute · Hanoi, Hanoi and 1 other locations · NCT07808164

• Olive oil before lung cancer surgery to see if it lowers chylothorax

  This study tests whether drinking 40 mL of extra-virgin olive oil a few hours before lung cancer surgery can reduce chylothorax after tumor removal.

  Recruiting Fudan University · Shanghai, Xuhui · NCT07807696

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.