Condition

Atherosclerotic Cardiovascular Disease clinical trials and research

• 13Clinical trials
• 30NIH research projects
• 9Countries

Newest Atherosclerotic Cardiovascular Disease clinical trials

All recruiting trials (13)

• Characterizing Subclinical ASCVD in Childhood Cancer Survivors

  This study tests whether detailed heart and blood vessel imaging and blood tests can reveal early signs of atherosclerosis in adult survivors of childhood cancer compared with community controls.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07594392

• HRS9531 for atherosclerotic cardiovascular disease

  This study tests whether HRS9531, compared with placebo, can reduce major adverse cardiovascular events in people with ASCVD.

  Recruiting Phase 3 Fujian Shengdi Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT07551492

• Long-term use of inclisiran, evolocumab, and alirocumab in real-world care

  This study tests whether people with high cholesterol medications stick with their PCSK9 inhibitors and inclisiran over the long term in everyday clinical practice.

  Recruiting Novartis · Basel · NCT07543731

• Targeted lipid optimization program to improve LDL-C control in adults with ASCVD

  This program will test whether a targeted education-based lipid optimization program helps adults with ASCVD and high LDL-C reach recommended LDL-C targets better than usual care.

  Recruiting Phase 4 Novartis · Abu Dhabi · NCT07034690

• Using a genetic blood-pressure risk score to guide care for adults with high blood pressure

  This trial will test whether giving adults aged 18–55 with hypertension and poor cardiovascular health their genetic risk score for systolic blood pressure plus structured genomic counseling helps them lower blood pressure and improve healthy habits over 12 months.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06962488

• Lipoprotein(a) levels in adults with atherosclerotic cardiovascular disease in Russia

  We will measure Lipoprotein(a) levels in adults with atherosclerotic cardiovascular disease in Russia and their relatives to see how common high levels are and whether they link to higher heart and stroke risk.

  Recruiting at 20 sites Novartis · Chelyabinsk and 19 other locations · NCT06858332

• Testing UDP-003 for safety and effectiveness in healthy individuals and patients with heart conditions

  This study is testing a new drug called UDP-003 to see if it's safe and effective for both healthy people and those with heart conditions, specifically looking at its ability to reduce plaque buildup in the arteries.

  Recruiting Early Phase 1 Cyclarity Therapeutics, Inc. · Adelaide, South Australia and 2 other locations · NCT06813339

• Managing LDL cholesterol levels in patients with cardiovascular disease through a pharmacist-led program

  This study is testing if a pharmacist-led program can help people with heart disease lower their LDL cholesterol levels better than regular care.

  Recruiting Intermountain Health Care, Inc. · Salt Lake City, Utah · NCT06571162

• Comparing enteric-coated and plain aspirin to reduce heart disease risks from air pollution

  This study is testing whether enteric-coated or plain low-dose aspirin can better help people with heart disease reduce their risks from air pollution, along with providing tips to stay healthy.

  Recruiting Rajaie Cardiovascular Medical and Research Center · Tehran, Tehran Province · NCT06541691

• Preventing coronary artery disease in young adults

  This study is testing if closely managing heart health in young adults aged 30-50 can slow down the buildup of artery plaque compared to regular care.

  Recruiting Phase 3 Icahn School of Medicine at Mount Sinai · New York, New York · NCT06494501

• Fish oil plus metformin for heart health in women with PCOS

  This trial will test whether taking dietary fish oil with metformin improves heart-related measures, blood fats, and insulin–glucose control in overweight women with PCOS, including some with type 2 diabetes.

  Recruiting at 3 sites Phase 1 University of Alberta · Edmonton, Alberta and 2 other locations · NCT06424860

• Lowering LDL cholesterol in older patients with heart disease

  This study is testing whether aiming for lower or higher LDL cholesterol levels can help older patients with heart disease stay healthier and avoid serious heart problems.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05765370

• Investigating the effects of pitavastatin and ezetimibe on glucose metabolism in patients with cardiovascular disease and metabolic syndrome

  This study is testing whether the medications pitavastatin alone or with ezetimibe can improve blood sugar levels in people with heart disease and metabolic syndrome who don't have diabetes.

  Recruiting Yonsei University · Seoul · NCT05705804

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrative model of metabolites, equol, and heart disease

  This grant looks at how a person’s body processes soy isoflavones into equol and how that relates to atherosclerotic heart disease, using complex data to build predictive models.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11411180

• Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients

  This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11402774

• PVAT and arteries: why some vessels resist plaque

  Aims to understand how fat tissue around arteries influences atherosclerosis, especially why the left internal mammary artery stays healthy while others don’t.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11401206

• How T cell genes and signals affect atherosclerosis

  This grant studies how a specific immune cell and its signals influence atherosclerosis in people, aiming to uncover new ways to reduce inflammation and heart disease risk.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11393308

• Understanding why some artery plaques become dangerous using genetics, tissue maps, and advanced imaging

  Researchers will combine human genetic data with single-cell and spatial tissue maps to find why certain atherosclerotic plaques are more likely to cause heart events, aiming to improve prediction and prevention.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11383446

• Opportunistic heart risk detection from abdominal CTs using robust AI

  A doctor-scientist team at Stanford will use existing abdominal CT scans and medical records to build a trustworthy AI tool that helps predict future heart problems in adults.

  NIH research Stanford University · Stanford, United States · NIH-11381592

• Extracellular Vesicles as Clues and Targets for Heart Disease in People with HIV

  This grant investigates how tiny particles in the blood, called extracellular vesicles, relate to heart disease risk in people living with HIV and looks for new ways to prevent or treat it.

  NIH research Vitalant · Scottsdale, United States · NIH-11380718

• Helping Veterans reduce their risk of heart disease with personalized statin therapy

  This study is looking to help Veterans who are at high risk for heart problems by using genetic testing to find out how well statins will work for them, so they can feel more confident about taking their medication and lower their cholesterol safely.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11353600

• How genes and blood metabolites relate to artery disease in diverse populations

  They are looking at whether blood metabolites and genetic differences help explain artery clogging in middle-aged and older adults from European, African American, and Hispanic backgrounds.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11309640

• Regulating artery disease with a long non-coding RNA called IRF1-AS1

  A study at NYU School of Medicine explores whether a special RNA molecule called IRF1-AS1 helps drive artery plaque and whether blocking it could reduce heart disease risk.

  NIH research New York University School of Medicine · New York, United States · NIH-11295561

• Familial hypercholesterolemia: closing gaps in prevention of heart disease

  A new NIH grant is exploring why people with familial hypercholesterolemia often go undiagnosed or receive uneven care, with the goal of improving early detection and prevention of heart disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11293026

• How the RNA CASLR affects artery plaque and risk of heart attack or stroke

  Researchers are looking at a molecule called CASLR to understand how it changes inflammation in artery plaques that can lead to heart attacks and strokes.

  NIH research New York University School of Medicine · New York, United States · NIH-11289449

• Kidney tubule health and heart disease risk in middle-aged and older adults

  This project uses urine markers of kidney tubule health to help identify middle-aged and older adults at higher risk for atherosclerotic heart disease and heart failure.

  NIH research Tufts Medical Center · Boston, United States · NIH-11237067

• Using genetics to personalize statin treatment for Veterans

  This project uses genetic test results to help Veterans at high risk for heart disease choose and stick with the right statin so they can lower their cholesterol and heart risk.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11173607

• How Lp(a) levels affect heart and artery disease risk in people with HIV

  This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11166455

• Equol, omega-3s, and artery‑clogging heart disease risk

  This project looks at whether making equol (a soy metabolite), levels of marine omega‑3s, and other blood metabolites link to atherosclerotic cardiovascular disease in people.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11166322

• Fairer heart attack and stroke risk prediction for adults with or at risk of atherosclerotic cardiovascular disease

  This project aims to build better risk tools to predict future heart attacks and strokes for adults with or at risk for atherosclerotic cardiovascular disease, including people from Hispanic and Asian communities.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11129856

• Using gene and tissue maps to understand artery plaque disease

  This project uses detailed maps of genes and tissue structure from human artery plaques to find what makes some plaques cause heart attacks or strokes.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11127552

• Tiny blood particles linked to heart disease risk in people living with HIV

  Researchers are looking at tiny particles called extracellular vesicles in adults with HIV on antiretroviral therapy to understand how they may relate to atherosclerotic heart disease risk.

  NIH research Vitalant · Scottsdale, United States · NIH-11098654

• How T cell genes and behavior affect artery-clogging heart disease

  This project looks at whether genetic differences that change regulatory T cells' activity affect inflammation and plaque buildup in people with atherosclerotic cardiovascular disease.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11096020

• AI that finds hidden heart disease risk in routine abdominal CT scans

  This project uses artificial intelligence on already-done abdominal CT scans and medical records to find people at higher risk for heart attack, stroke, or cardiovascular death.

  NIH research Stanford University · Stanford, United States · NIH-11094820

• Investigating how long noncoding RNA affects heart disease

  This study is looking at how certain molecules in our cells, called long noncoding RNAs, might affect heart disease and inflammation, helping us understand their role in conditions like atherosclerosis, which can lead to heart attacks and strokes.

  NIH research New York University School of Medicine · New York, United States · NIH-11053621

• Understanding the genetic and metabolic factors of heart disease in diverse populations

  This study is looking at how our genes and body processes affect heart disease in people from different backgrounds, and it's for anyone interested in understanding what might increase their risk of heart problems.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11052508

• Investigating how aspirin affects weight and heart disease risk

  This study is looking at how taking a small daily dose of aspirin might help improve heart health for people who are overweight or have artery problems, by reducing inflammation and other risks related to heart disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11045727

• How lipoprotein(a) affects heart disease risk in people with HIV

  This study is looking at how levels of a substance called lipoprotein(a) might affect the heart health of people living with HIV, especially since chronic inflammation can play a role, and it will also explore differences in these levels between Black and White individuals.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11009218

• Investigating kidney tubule health and its impact on heart disease in older adults

  This study is looking at how the health of tiny tubes in your kidneys might influence your chances of developing heart disease as you get older, using new urine tests to find out more about your kidney health and help identify those who may be at higher risk.

  NIH research Tufts Medical Center · Boston, United States · NIH-10990998

• Investigating the link between cytomegalovirus and heart disease in people with HIV

  This study is looking at how a virus called cytomegalovirus (CMV) might affect heart health in people living with HIV, by checking how the immune system responds to the virus and its possible link to heart problems.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10895350

• Improving risk assessment for heart disease

  This study is looking to improve how we figure out who is at risk for heart disease by considering important social factors and other details that are often missed, especially for people from minority groups, so we can better decide when to start or change cholesterol-lowering treatments like statins.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10884400

• Improving statin use among Veterans at risk for heart disease through genetic testing

  This study is looking to help Veterans who are at high risk for heart problems by using genetic testing to show how their genes affect how well statins work for them, making it easier for them to understand and stick with their treatment for better heart health.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-10750662

• Investigating how immune complexes involving a protein called ApoA-I affect heart disease

  This study is looking at how certain immune proteins in your body might help reduce inflammation and improve heart health for people with atherosclerotic cardiovascular disease (ASCVD).

  NIH research University of Kentucky · Lexington, United States · NIH-10634607

Related topics

Quick answers

How many Atherosclerotic Cardiovascular Disease clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (4 trials), China (2 trials), Russia (1 trial), United Arab Emirates (1 trial), Iran (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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