Investigating how long noncoding RNA affects heart disease
Long noncoding RNA regulation of Atherosclerotic Cardiovascular Disease
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11053621
This study is looking at how certain molecules in our cells, called long noncoding RNAs, might affect heart disease and inflammation, helping us understand their role in conditions like atherosclerosis, which can lead to heart attacks and strokes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11053621 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of long noncoding RNAs in atherosclerotic cardiovascular disease (ASCVD), which is a leading cause of death globally. By utilizing human tissues and animal models, the study aims to identify specific long noncoding RNAs that regulate inflammatory responses and gene expression related to heart disease. The researchers will employ advanced techniques, including predictive bioinformatics and deep molecular phenotyping, to explore how these molecules contribute to the progression of atherosclerosis and the risk of heart attacks or strokes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerotic cardiovascular disease.
Not a fit: Patients with non-atherosclerotic cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for preventing and treating atherosclerotic cardiovascular disease.
How similar studies have performed: Previous research has shown promise in targeting noncoding RNAs for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOORE, KATHRYN J — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: MOORE, KATHRYN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.