Investigating how long noncoding RNA affects heart disease
Official title: Long noncoding RNA regulation of Atherosclerotic Cardiovascular Disease
Funded at New York University School of Medicine · NIH-11053621 · Data updated 2026-11-12
This study is looking at how certain molecules in our cells, called long noncoding RNAs, might affect heart disease and inflammation, helping us understand their role in conditions like atherosclerosis, which can lead to heart attacks and strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $658,658 |
| NIH project number | 5R01HL172335-02 |
| Project ID | NIH-11053621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerotic cardiovascular disease.
✕Less likely to help
Patients with non-atherosclerotic cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of long noncoding RNAs in atherosclerotic cardiovascular disease (ASCVD), which is a leading cause of death globally. By utilizing human tissues and animal models, the study aims to identify specific long noncoding RNAs that regulate inflammatory responses and gene expression related to heart disease. The researchers will employ advanced techniques, including predictive bioinformatics and deep molecular phenotyping, to explore how these molecules contribute to the progression of atherosclerosis and the risk of heart attacks or strokes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for preventing and treating atherosclerotic cardiovascular disease.
How similar studies have gone: Previous research has shown promise in targeting noncoding RNAs for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Moore, Kathryn J — New York University School of Medicine
- Study coordinator: Moore, Kathryn J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.