Understanding the genetic and metabolic factors of heart disease in diverse populations
Official title: Molecular Determinants of Atherosclerotic Cardiovascular Disease in Multi-ethnic Populations
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11052508 · Data updated 2026-11-12
This study is looking at how our genes and body processes affect heart disease in people from different backgrounds, and it's for anyone interested in understanding what might increase their risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $637,515 |
| NIH project number | 5R01HL168683-03 |
| Project ID | NIH-11052508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include middle-aged and older individuals from multi-ethnic backgrounds, particularly those at risk for atherosclerotic cardiovascular disease.
✕Less likely to help
Patients who are younger and have no risk factors for cardiovascular disease may not receive benefit from this research.
What this research studies
This research investigates how genetic variants and metabolic processes contribute to atherosclerotic cardiovascular disease (ASCVD) in multi-ethnic populations. By analyzing circulating metabolites and their relationship with genetic determinants, the study aims to uncover the mechanisms behind atherosclerosis progression. The research will utilize data from the Trans-Omics for Precision Medicine (TOPMed) Program, focusing on diverse groups including European, African, and Hispanic Americans. Participants' genetic and metabolic profiles will be examined to identify risk factors for ASCVD.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for heart disease tailored to diverse populations.
How similar studies have gone: Previous research has shown promise in understanding metabolic influences on atherosclerosis, but this approach focusing on multi-ethnic populations is relatively novel.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Yu, Bing — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yu, Bing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.