How T cell genes and behavior affect artery-clogging heart disease
Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11096020
This project looks at whether genetic differences that change regulatory T cells' activity affect inflammation and plaque buildup in people with atherosclerotic cardiovascular disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11096020 on ClinicalTrials.gov |
What this research studies
You would contribute blood and DNA samples so researchers can measure regulatory T cells and the level of CD39, a molecule that helps control inflammation. The team will compare people with different genetic variants to see how those variants change T cell behavior and inflammation related to artery plaque. In the lab, they will use antisense oligonucleotides and cell or animal models to raise or lower CD39 and observe effects on inflammatory signals and plaque development. The combined human and lab work aims to link specific genetic changes to immune function and atherosclerosis.
Who could benefit from this research
Good fit: Adults with diagnosed atherosclerotic cardiovascular disease who are willing to provide blood and genetic samples would be the most relevant candidates to participate.
Not a fit: People without atherosclerosis or those seeking an immediate new clinical treatment are unlikely to get direct medical benefit from participating.
Why it matters
Potential benefit: If successful, this work could point to new immune-based treatments that boost Treg CD39 activity to lower inflammation and reduce atherosclerotic complications.
How similar studies have performed: Related approaches targeting CD39 or Treg function have shown promise in other inflammatory diseases, but applying CD39 modulation specifically to atherosclerosis is a newer direction.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUMINA, RICHARD J — OHIO STATE UNIVERSITY
- Study coordinator: GUMINA, RICHARD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease