How lipoprotein(a) affects heart disease risk in people with HIV
Official title: Lipoprotein (a) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular Disease
Funded at Johns Hopkins University · NIH-11009218 · Data updated 2026-11-12
This study is looking at how levels of a substance called lipoprotein(a) might affect the heart health of people living with HIV, especially since chronic inflammation can play a role, and it will also explore differences in these levels between Black and White individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $742,803 |
| NIH project number | 1R01HL176322-01 |
| Project ID | NIH-11009218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV, particularly those who may be at risk for cardiovascular disease.
✕Less likely to help
Patients who do not have HIV or those without cardiovascular disease risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between lipoprotein(a) levels and the risk of atherosclerotic cardiovascular disease (ASCVD) in individuals living with HIV. It aims to identify specific thresholds of lipoprotein(a) that correlate with increased ASCVD risk, particularly in the context of chronic inflammation associated with HIV. The study will utilize data from the MACS/WIHS Combined Cohort Study to analyze subclinical ASCVD and explore potential mechanisms linking lipoprotein(a) to heightened cardiovascular risk. Additionally, it will examine racial disparities in lipoprotein(a) levels, focusing on differences between Black and White populations.
Why it matters
Potential benefit: If successful, this research could lead to improved risk prediction and targeted therapies for cardiovascular disease in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding cardiovascular risks in HIV populations, but this specific focus on lipoprotein(a) is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Leucker, Thorsten M — Johns Hopkins University
- Study coordinator: Leucker, Thorsten M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.