Helping Veterans reduce their risk of heart disease with personalized statin therapy
Official title: Reducing Veterans' Risk of Atherosclerotic Cardiovascular Disease Through Pharmacogenomics Informed Statin Prescribing
Funded at Durham VA Medical Center · NIH-11353600 · Data updated 2026-11-12
This study is looking to help Veterans who are at high risk for heart problems by using genetic testing to find out how well statins will work for them, so they can feel more confident about taking their medication and lower their cholesterol safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Durham VA Medical Center NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| NIH project number | 7I01HX003477-02 |
| Project ID | NIH-11353600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans who are at high risk for cardiovascular disease and are currently not taking statins.
✕Less likely to help
Patients who are already effectively managing their cardiovascular risk with statins or those who do not have a high risk for cardiovascular disease may not benefit from this research.
What this research studies
This research aims to improve the use of statins among Veterans at high risk for cardiovascular disease by utilizing pharmacogenomic testing. By understanding how individual genetic variations affect statin efficacy and toxicity, the study seeks to enhance patients' perceptions of the benefits and risks associated with statin therapy. The approach involves disclosing pharmacogenomic test results to patients, which is expected to increase their acceptance and adherence to statin medications, ultimately leading to lower cholesterol levels and reduced cardiovascular risk.
Why it matters
Potential benefit: If successful, this research could lead to more Veterans effectively managing their cholesterol levels and reducing their risk of cardiovascular disease.
How similar studies have gone: Previous research has shown that pharmacogenomic testing can significantly improve statin prescribing practices and patient outcomes, indicating a promising approach.
Where this research is happening
-
Durham VA Medical Center
Durham, United States Active
Researchers
- Principal investigator: Voora, Deepak — Durham VA Medical Center
- Study coordinator: Voora, Deepak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.