Helping Veterans reduce their risk of heart disease with personalized statin therapy
Reducing Veterans' Risk of Atherosclerotic Cardiovascular Disease Through Pharmacogenomics Informed Statin Prescribing
This study is looking to help Veterans who are at high risk for heart problems by using genetic testing to find out how well statins will work for them, so they can feel more confident about taking their medication and lower their cholesterol safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Durham VA Medical Center NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11353600 on NIH RePORTER |
What this research studies
This research aims to improve the use of statins among Veterans at high risk for cardiovascular disease by utilizing pharmacogenomic testing. By understanding how individual genetic variations affect statin efficacy and toxicity, the study seeks to enhance patients' perceptions of the benefits and risks associated with statin therapy. The approach involves disclosing pharmacogenomic test results to patients, which is expected to increase their acceptance and adherence to statin medications, ultimately leading to lower cholesterol levels and reduced cardiovascular risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans who are at high risk for cardiovascular disease and are currently not taking statins.
Not a fit: Patients who are already effectively managing their cardiovascular risk with statins or those who do not have a high risk for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more Veterans effectively managing their cholesterol levels and reducing their risk of cardiovascular disease.
How similar studies have performed: Previous research has shown that pharmacogenomic testing can significantly improve statin prescribing practices and patient outcomes, indicating a promising approach.
Where this research is happening
Durham, United States
- Durham VA Medical Center — Durham, United States (Active)
Researchers
- Principal investigator: Voora, Deepak — Durham VA Medical Center
- Study coordinator: Voora, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.