Investigating how immune complexes involving a protein called ApoA-I affect heart disease
Official title: Understanding the role of immune complexes between apolipoprotein A-I and IgG in atherosclerotic cardiovascular disease
Funded at University of Kentucky · NIH-10634607 · Data updated 2026-11-12
This study is looking at how certain immune proteins in your body might help reduce inflammation and improve heart health for people with atherosclerotic cardiovascular disease (ASCVD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $375,958 |
| NIH project number | 5R01HL152081-04 |
| Project ID | NIH-10634607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atherosclerotic cardiovascular disease.
✕Less likely to help
Patients without atherosclerotic cardiovascular disease or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of immune complexes formed between apolipoprotein A-I (ApoA-I) and IgG antibodies in patients with atherosclerotic cardiovascular disease (ASCVD). The study aims to characterize these immune complexes and their anti-inflammatory properties, which may help reduce the risk of cardiovascular disease. By analyzing samples from both mice and human patients, the researchers will explore how these immune interactions influence inflammation and disease progression. The ultimate goal is to uncover how these immune responses can be harnessed to improve patient outcomes in ASCVD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerotic cardiovascular disease by targeting immune responses.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Venditto, Vincent Joseph — University of Kentucky
- Study coordinator: Venditto, Vincent Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.