Improving tendon-to-bone healing after ACL surgery
Localized small molecule delivery to improve tendon-to-bone integration following anterior cruciate ligament reconstruction
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10978736
This study is looking at a new way to help your knee heal better after ACL surgery by using special treatments right where the tendon connects to the bone, which could make recovery faster and reduce the chances of problems later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10978736 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the healing process of the tendon-to-bone connection following anterior cruciate ligament (ACL) reconstruction. It aims to utilize localized small molecule delivery to promote the formation of a strong and functional attachment site, which is crucial for recovery. By targeting specific biological pathways involved in tissue regeneration, the study seeks to reduce the risk of graft failure and improve overall outcomes for patients. The approach involves innovative techniques to deliver therapeutic agents directly to the site of injury, potentially leading to faster and more effective healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have suffered an ACL injury and are scheduled for reconstruction surgery.
Not a fit: Patients who have already undergone ACL reconstruction or those with other knee injuries unrelated to the ACL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing ACL reconstruction.
How similar studies have performed: Previous research has shown promise in using targeted biological pathways to enhance tissue healing, suggesting that this approach may be effective.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DYMENT, NATHANIEL A. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: DYMENT, NATHANIEL A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: ACL injury