Split-belt treadmill training to restore knee loading after ACL surgery

Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction

NIH-funded research University of Michigan at Ann Arbor · NIH-11266154

This project uses split-belt treadmill walking to help people who had ACL reconstruction regain more normal loading on their repaired knee during everyday activities.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11266154 on NIH RePORTER

What this research studies

You would walk on a treadmill with the two belts set to different speeds so one leg works differently than the other, which can retrain how you load your surgical knee. Researchers will measure walking forces and knee mechanics in 3-D before and after these training sessions to see if the surgical limb takes on more load. The team will test different belt speed settings and which limb to train to find the most helpful approach. They will also check whether any changes last after the session ends.

Who could benefit from this research

Good fit: Ideal candidates are people who have had ACL reconstruction and are cleared to walk and participate in supervised treadmill-based rehabilitation.

Not a fit: People who have not had ACL reconstruction, are not cleared for treadmill walking, or have conditions preventing safe participation (severe balance, other major lower-limb injuries) are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, this approach could help reduce underloading of the surgical knee and lower the risk of re-injury and later osteoarthritis.

How similar studies have performed: Split-belt treadmill training has changed walking mechanics in healthy and neurological populations and the investigators' pilot data show promising increases in ACL limb loading, but it has not yet been systematically proven for ACL-reconstructed patients.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions ACL injury
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.