Condition

Alcoholic Liver Disease clinical trials and research

• 10Clinical trials
• 28NIH research projects
• 5Countries

Newest Alcoholic Liver Disease clinical trials

All recruiting trials (10)

• Exploring the role of gut bacteria in alcoholic hepatitis

  This study is trying to see how gut bacteria affect liver damage in people with severe alcoholic hepatitis to find new ways to help them feel better.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06307964

• Cohort study on the impact of gut microbiome in alcoholic liver disease

  This study is trying to see how the gut bacteria of heavy drinkers affects the development and worsening of alcoholic liver disease.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clamart, Île-de-France Region · NCT05895890

• Evaluating liver disease screening for individuals with alcohol use disorder

  This study tests if screening for liver disease with a special measurement helps people in alcohol treatment stay sober or drink less over six months.

  Recruiting at 2 sites Zealand University Hospital · Køge and 1 other locations · NCT05855031

• HMB supplementation for patients with alcoholic liver disease and COVID-19

  This study is testing if HMB supplements can help people with alcoholic liver disease who also have COVID-19 feel better and recover more effectively.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04858412

• Improving early diagnosis of liver disease using integrated diagnostics

  This study is trying to improve how quickly and accurately liver disease is diagnosed by combining different tests and information from around 750 patients who are at risk or have abnormal liver blood tests.

  Recruiting Manchester University NHS Foundation Trust · Manchester, Greater Manchester · NCT04666402

• Understanding Alcohol-related Liver Disease in Europe

  This study looks at how alcohol-related liver disease develops in heavy drinkers to see if non-invasive tests can help identify those at risk of serious liver damage.

  Recruiting University Hospital, Lille · Lille · NCT04400604

• Effects of a fermented powder on liver disease caused by alcohol

  This study is testing if a special fermented powder can help adults with liver disease caused by alcohol feel better over eight weeks.

  Recruiting Pusan National University Yangsan Hospital · Pusan, Ami-dong · NCT04320199

• Understanding genetic factors in alcoholic liver disease

  This study looks at how common alcoholic hepatitis is in people with jaundice and tries to understand the role of genetics in the disease while also testing new ways to diagnose it.

  Recruiting at 9 sites University Hospital, Lille · Angers and 8 other locations · NCT04106518

• Evaluating alcohol use in patients with alcoholic liver disease

  This study is trying to see how often people with alcoholic liver disease go back to drinking alcohol over a period of up to 10 years.

  Recruiting New York Presbyterian Hospital · New York, New York · NCT03267069

• Ethanol's effect on muscle autophagy in alcoholic liver disease

  This study is testing how alcohol affects muscle health in people with alcoholic liver disease by looking at how it breaks down certain proteins in their muscles.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03209791

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Microbiome and Innate Immune Response in Alcohol-Related Liver Disease

  Researchers are studying how gut bacteria and the body's first-line immune defenses contribute to liver damage from alcohol, with a focus on how a specific bacteria and its toxins affect disease severity.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11543368

• Lipotoxicity and Alcohol-Related Liver Disease

  This project studies how fatty acids cause liver cell damage in alcohol-related liver disease to help develop new treatments.

  NIH research University of North Carolina Greensboro · Greensboro, United States · NIH-11450399

• NNMT as a Target to Treat Alcoholic Liver Disease

  A study to see if blocking an enzyme called NNMT can help people with alcoholic liver disease.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11380807

• How gut fungi may drive alcohol-related liver damage

  Researchers are looking at whether specific fungi in the gut make liver damage from heavy drinking worse in people with alcohol-related liver disease.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11378956

• Heat shock protein 90 and alcohol-related liver disease: how macrophages fuel inflammation

  This project looks at how a cellular stress protein, HSP90, affects liver inflammation in people with alcohol-related liver disease by focusing on macrophages.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11374847

• Why alcohol-related liver disease can come back after a transplant

  Looking at whether an enzyme called CerS6 helps fat build up in the liver and whether measuring CerS6 can help detect or predict return of alcohol-related liver disease before or after a liver transplant.

  NIH research University of Washington · Seattle, United States · NIH-11329541

• Harmful gut bacteria linked to alcohol-related liver damage

  This work looks at whether certain harmful gut bacteria make liver disease worse in people who drink heavily.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11212762

• Immune signals driving alcohol-related liver damage

  This project tests whether blocking a key immune protein (BTK) and stopping neutrophil extracellular traps can reduce inflammation and liver injury in people with alcohol-associated hepatitis.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11194417

• Therapy to protect liver and kidneys in alcoholic liver disease-related hepatorenal syndrome

  This project is testing whether the supplement nicotinamide riboside to boost NAD+ can help people with alcoholic liver disease who develop hepatorenal syndrome and acute kidney injury.

  NIH research Mitopower LLC · Palo Alto, United States · NIH-11161451

• Liver protein complex that drives inflammation and gut damage in alcohol-related liver disease

  This project looks at how a protein released from the liver sparks inflammation that harms both the liver and the gut in people with alcohol-related liver disease.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-11131054

• Understanding how a protein called HSP90 affects alcoholic liver disease

  This work explores how a specific protein, HSP90, influences immune cells in the liver to better understand and treat alcoholic liver disease.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11129841

• Gut bacteria and immune responses in alcohol-related liver damage

  This work looks at how certain gut bacteria and their toxin may worsen liver damage in people who drink heavily.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11123423

• Investigating the role of sphingolipids in liver disease caused by alcohol.

  This study is looking at how alcohol impacts liver health and aims to find new ways to help people with alcoholic liver disease by understanding the role of certain molecules and the gut bacteria involved.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11105882

• Targeting a liver enzyme (NNMT) to treat alcohol-related liver damage

  Seeing if blocking a liver enzyme called NNMT can prevent or reduce alcohol-related liver damage for people with alcoholic liver disease.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11098669

• Understanding how alcohol affects muscle health in liver disease

  This study looks at how drinking alcohol affects muscle health in people with alcoholic liver disease, aiming to understand why they often lose muscle and find ways to help improve their strength and well-being.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11032829

• Investigating a new signaling pathway in alcoholic liver disease

  This study is looking at how a new way that liver cells talk to immune cells might help protect the liver from damage caused by drinking alcohol, and it's aimed at finding new treatments for people with alcoholic liver disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11018509

• Investigating how certain bacteria contribute to liver disease caused by alcohol use

  This study is looking at how certain bacteria in the gut might make liver problems worse for people with alcohol use disorder, and it aims to find new ways to help those dealing with liver issues.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-10950315

• Understanding a new enzyme's role in alcoholic liver disease

  This study is looking at a new enzyme called HKDC1 to see how it might help protect the liver from damage caused by drinking alcohol, which could lead to better treatments for people with alcoholic liver disease.

  NIH research Loyola University Chicago · Maywood, United States · NIH-10930893

• New treatment for kidney problems caused by alcoholic liver disease

  This study is testing a new treatment using a supplement called nicotinamide riboside to help improve kidney and liver health in people with hepatorenal syndrome caused by alcoholic liver disease.

  NIH research Mitopower LLC · Palo Alto, United States · NIH-10920469

• Investigating how a liver protein complex contributes to inflammation and injury in alcoholic liver disease

  This study is looking at how a certain protein from the liver might cause inflammation and damage in the liver and intestines of people with alcoholic liver disease, and it hopes to find ways to help improve gut health and reduce the harmful effects of alcohol.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-10911018

• Investigating how a specific receptor affects liver disease in women with alcohol use.

  This study is looking into why women with alcoholic liver disease tend to have more severe symptoms than men, focusing on how certain biological factors and hormones affect liver health in women who drink alcohol.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10883611

• Creating a mouse model to study liver disease caused by alcohol

  This study is creating a new mouse model to better understand alcoholic liver disease, helping researchers learn how alcohol impacts liver cells, which could lead to better treatments for people affected by this condition.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10853113

• Investigating how liver cells communicate in alcoholic liver disease

  This study is looking at how liver cells talk to immune cells when someone has alcoholic liver disease, by checking how tiny signals from damaged liver cells might affect liver health, with the hope of finding new ways to help treat this condition.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10816603

• Understanding how a specific protein affects liver disease caused by alcohol.

  This study is looking at how a protein called Ctgf affects liver damage in people with alcohol-related liver problems, with the goal of finding new treatments that could help heal their livers.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-10765653

• Using cannabidiol to treat alcoholic liver disease

  This study is looking at whether taking cannabidiol (CBD), a compound from cannabis that doesn’t get you high, can help protect the liver from damage caused by drinking alcohol, and it's aimed at people who have alcoholic liver disease.

  NIH research University of Louisville · Louisville, United States · NIH-10753729

• Investigating how alcohol affects mitochondrial function in liver disease

  This study is looking at how drinking alcohol affects tiny parts of your liver cells called mitochondria, which help keep your liver healthy, and it's for anyone interested in understanding more about how alcohol can impact liver health.

  NIH research Northeast Ohio Medical University · Rootstown, United States · NIH-10706527

• Investigating a new treatment for alcoholic liver disease

  This study is looking at a new treatment called nicotinamide fumarate (NMF) to see if it can help people with alcoholic liver disease, and it will compare how well it works against another drug, RTA408, using mice to learn more about how these treatments might help in the future.

  NIH research University of California at Davis · Davis, United States · NIH-10700042

• Understanding how fat breakdown processes are affected by alcohol in liver disease

  This study is looking at how alcohol affects the way your liver breaks down fat, which could help find new treatments for alcoholic liver disease.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10686384

Related topics

Quick answers

How many Alcoholic Liver Disease clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in France (4 trials), United States (3 trials), United Kingdom (1 trial), Denmark (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →