Cohort study on the impact of gut microbiome in alcoholic liver disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of the intestinal microbiome in the development and progression of alcoholic liver disease (ALD) among heavy drinkers. Participants will be recruited based on their alcohol consumption and will undergo sequential sampling of stool, saliva, and serum to analyze microbiome composition and its potential effects on liver health. The study seeks to identify factors beyond alcohol intake that contribute to the onset of conditions like acute alcoholic hepatitis and cirrhosis. By understanding these relationships, the research aims to provide insights into better management strategies for ALD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 75 years
* Average alcohol consumption of more than 20 g per day in women and 30 g per day in men during the previous year;
* Patients seen in consultation or hospitalized for assessment of alcoholic liver disease and management of alcohol addiction;
* Having given their consent to participate in this study;
* Affiliated to a social security system (beneficiary or beneficiary's right).

Exclusion Criteria:

* Antibiotic, probiotic or prebiotic treatment within the previous 3 months ;
* Digestive hemorrhage, acute pancreatitis, acute or chronic diarrhea (except diarrhea related to excessive alcohol consumption) or chronic inflammatory bowel disease;
* Another cause of liver damage;
* A serious associated pathology (respiratory failure, heart failure, severe psychiatric disorders, active cancer).
* Patient under guardianship or curatorship

Where it's running

• Cosmin Voican
  Clamart, Île-de-France Region, France Recruiting

Study contacts

• Principal investigator: Cosmin Voican, Dr — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Cosmin Voican, Dr
• Email: cosmin.voican@aphp.fr
• Phone: 01 45 37 47 75

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.