Investigating how alcohol affects mitochondrial function in liver disease
Official title: Mitochondrial Acetylation and Acetylome Dynamics in Alcoholic Liver Disease assessed with Heavy Water
Funded at Northeast Ohio Medical University · NIH-10706527 · Data updated 2026-11-12
This study is looking at how drinking alcohol affects tiny parts of your liver cells called mitochondria, which help keep your liver healthy, and it's for anyone interested in understanding more about how alcohol can impact liver health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $187,860 |
| NIH project number | 5R21AA029784-02 |
| Project ID | NIH-10706527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol consumption who may be at risk for alcoholic liver disease.
✕Less likely to help
Patients who do not consume alcohol or have no liver-related health issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial acetylation in alcoholic liver disease (ALD). It aims to explore how alcohol intake leads to changes in the dynamics of acetylation in liver mitochondria, which may impact their function. Using advanced techniques like high-resolution liquid chromatography-tandem mass spectrometry, the study will analyze the acetylome dynamics in liver tissues from mice with ALD. The goal is to determine how these changes affect mitochondrial protein stability and function over time.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of alcoholic liver disease and potential therapeutic targets for treatment.
How similar studies have gone: While the specific approach of assessing acetylome dynamics in the context of alcoholic liver disease is relatively novel, similar studies have shown promising results in understanding mitochondrial function in other contexts.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Kasumov, Takhar — Northeast Ohio Medical University
- Study coordinator: Kasumov, Takhar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.