Understanding how alcohol affects muscle health in liver disease
Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease
This study looks at how drinking alcohol affects muscle health in people with alcoholic liver disease, aiming to understand why they often lose muscle and find ways to help improve their strength and well-being.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11032829 on NIH RePORTER |
What this research studies
This research investigates the impact of alcohol use on skeletal muscle health in patients with alcoholic liver disease (ALD). It focuses on the mechanisms that lead to muscle loss, known as sarcopenia, which is common in ALD and linked to worse health outcomes. The study examines how alcohol consumption disrupts protein homeostasis and causes mitochondrial dysfunction, contributing to muscle deterioration. By exploring these underlying processes, the research aims to identify potential therapeutic targets for improving muscle health in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic liver disease who are experiencing muscle loss or sarcopenia.
Not a fit: Patients without alcoholic liver disease or those who do not exhibit muscle loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve muscle mass and improve health outcomes for patients with alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding muscle loss mechanisms in liver disease, but this specific approach focusing on HIF1α and alcohol's effects is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Welch, Nicole — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Welch, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.