Investigating how a liver protein complex contributes to inflammation and injury in alcoholic liver disease
Pathogenic role of a protein complex of liver origin as regulator of a proinflammatory program that drives hepatic and intestinal injury in alcoholic liver disease
['FUNDING_OTHER'] · JESSE BROWN VA MEDICAL CENTER · NIH-10911018
This study is looking at how a certain protein from the liver might cause inflammation and damage in the liver and intestines of people with alcoholic liver disease, and it hopes to find ways to help improve gut health and reduce the harmful effects of alcohol.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JESSE BROWN VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10911018 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific protein complex from the liver that may trigger inflammation and damage in both the liver and intestines of individuals suffering from alcoholic liver disease. The study aims to explore how liver-derived signals can affect gut health and contribute to a cycle of inflammation. By examining the mechanisms involved, researchers hope to identify potential therapeutic targets that could mitigate the harmful effects of alcohol on the body. Patients may be involved in providing samples or data to help elucidate these pathways.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with alcoholic liver disease or those experiencing related gastrointestinal issues.
Not a fit: Patients without a history of alcohol use or those with non-alcoholic liver diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve outcomes for patients with alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding liver-gut interactions in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
CHICAGO, UNITED STATES
- JESSE BROWN VA MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIETO, NATALIA — JESSE BROWN VA MEDICAL CENTER
- Study coordinator: NIETO, NATALIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcoholic Liver Diseases