Creating a mouse model to study liver disease caused by alcohol
Multicellular Organotypic Mouse Model of Alcoholic Liver Disease
This study is creating a new mouse model to better understand alcoholic liver disease, helping researchers learn how alcohol impacts liver cells, which could lead to better treatments for people affected by this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10853113 on NIH RePORTER |
What this research studies
This research focuses on developing a new mouse model that accurately mimics alcoholic liver disease (ALD), which is a significant health issue related to alcohol consumption. The researchers aim to understand the mechanisms of ALD by using advanced techniques to create three-dimensional liver microtissues that maintain the functionality of liver cells. This model will allow for better investigation of how alcohol affects different types of liver cells and their interactions, which is crucial for understanding the disease's progression. By improving the model, the research seeks to provide insights that could lead to more effective treatments for ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have liver diseases unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from alcoholic liver disease.
How similar studies have performed: Previous research has shown success in using advanced models to study liver diseases, indicating that this approach has the potential to yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Khetani, Salman R — University of Illinois at Chicago
- Study coordinator: Khetani, Salman R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.