Creating a mouse model to study liver disease caused by alcohol
Official title: Multicellular Organotypic Mouse Model of Alcoholic Liver Disease
Funded at University of Illinois at Chicago · NIH-10853113 · Data updated 2026-11-12
This study is creating a new mouse model to better understand alcoholic liver disease, helping researchers learn how alcohol impacts liver cells, which could lead to better treatments for people affected by this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $189,094 |
| NIH project number | 5R21AA030397-02 |
| Project ID | NIH-10853113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver-related health issues.
✕Less likely to help
Patients who do not consume alcohol or have liver diseases unrelated to alcohol may not benefit from this research.
What this research studies
This research focuses on developing a new mouse model that accurately mimics alcoholic liver disease (ALD), which is a significant health issue related to alcohol consumption. The researchers aim to understand the mechanisms of ALD by using advanced techniques to create three-dimensional liver microtissues that maintain the functionality of liver cells. This model will allow for better investigation of how alcohol affects different types of liver cells and their interactions, which is crucial for understanding the disease's progression. By improving the model, the research seeks to provide insights that could lead to more effective treatments for ALD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from alcoholic liver disease.
How similar studies have gone: Previous research has shown success in using advanced models to study liver diseases, indicating that this approach has the potential to yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Khetani, Salman R — University of Illinois at Chicago
- Study coordinator: Khetani, Salman R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.