Investigating how liver cells communicate in alcoholic liver disease
Hepatocyte-derived extracellular vesicles in alcoholic liver disease
This study is looking at how liver cells talk to immune cells when someone has alcoholic liver disease, by checking how tiny signals from damaged liver cells might affect liver health, with the hope of finding new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10816603 on NIH RePORTER |
What this research studies
This research focuses on understanding the communication between liver cells and other immune cells in the context of alcoholic liver disease (ALD). It examines how damaged liver cells release small vesicles that carry important molecular signals, which may influence the progression of liver damage. By studying these interactions, the research aims to uncover the mechanisms that lead to severe liver conditions, potentially paving the way for new treatments. The approach involves analyzing blood samples from models of ALD to track these vesicles and their effects on other cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver-related issues, such as fatty liver or inflammation.
Not a fit: Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding cell communication in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Feldstein, Ariel — University of California, San Diego
- Study coordinator: Feldstein, Ariel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.