Understanding how a specific protein affects liver disease caused by alcohol.
Regulation of the pro-fibrotic connective tissue growth factor in alcoholic liver disease: mechanisms and targeting approaches
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-10765653
This study is looking at how a protein called Ctgf affects liver damage in people with alcohol-related liver problems, with the goal of finding new treatments that could help heal their livers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10765653 on ClinicalTrials.gov |
What this research studies
This research investigates the role of connective tissue growth factor (Ctgf) in alcoholic liver disease, focusing on how it contributes to liver fibrosis and cirrhosis. The study aims to explore the mechanisms by which Ctgf promotes liver damage and to identify potential therapeutic approaches to target this protein. By examining the interactions between liver cells and Ctgf, researchers hope to develop new anti-fibrotic drugs that could slow or reverse liver damage in patients with chronic liver disease. This research is particularly relevant for individuals suffering from alcohol-induced liver injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic liver disease or chronic liver disease characterized by fibrosis.
Not a fit: Patients with liver disease not related to alcohol consumption or those with advanced cirrhosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse liver fibrosis in patients with alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in liver disease, indicating potential for success in this approach.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PI, LIYA — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: PI, LIYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder